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  1. Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ f...

    Authors: Manu Shankar-Hari, Peter S Kruger, Stefania Di Gangi, Damon C Scales, Gavin D Perkins, Danny F McAuley and Marius Terblanche
    Citation: BMC Clinical Pharmacology 2012 12:13
  2. Observational data are increasingly being used for pharmacoepidemiological, health services and clinical effectiveness research. Since pharmacies first introduced low-cost prescription programs (LCPP), researc...

    Authors: Vivienne J Zhu, Anne Belsito, Wanzhu Tu and J Marc Overhage
    Citation: BMC Clinical Pharmacology 2012 12:12
  3. Paracetamol (acetaminophen) is generally considered a safe medication, but is associated with hepatotoxicity at doses above doses of 4.0g/day, and even below this daily dose in certain populations.

    Authors: Roderick Clark, Judith E Fisher, Ingrid S Sketris and Grace M Johnston
    Citation: BMC Clinical Pharmacology 2012 12:11
  4. Medication-taking behavior, specifically non-adherence, is significantly associated with treatment outcome and is a major cause of relapse in the treatment of psychotic disorders. Non-adherence can be multifac...

    Authors: Menna Alene, Michael D Wiese, Mulugeta T Angamo, Beata V Bajorek, Elias A Yesuf and Nasir Tajure Wabe
    Citation: BMC Clinical Pharmacology 2012 12:10
  5. An accurate medication list at hospital admission is essential for the evaluation and further treatment of patients. The objective of this study was to describe the frequency, type and predictors of errors in ...

    Authors: Lina M Hellström, Åsa Bondesson, Peter Höglund and Tommy Eriksson
    Citation: BMC Clinical Pharmacology 2012 12:9
  6. Consistent with its effect on gastric emptying, exenatide, an injectable treatment for type 2 diabetes, may slow the absorption rate of concomitantly administered oral drugs resulting in a decrease in maximum ...

    Authors: Prajakti A Kothare, Mary E Seger, Justin Northrup, Kenneth Mace, Malcolm I Mitchell and Helle Linnebjerg
    Citation: BMC Clinical Pharmacology 2012 12:8
  7. Data on adverse drug reactions (ADRs) related to antiretroviral (ARV) use in public health practice are few indicating the need for ART safety surveillance in clinical care.

    Authors: George I Eluwa, Titilope Badru and Kesiena J Akpoigbe
    Citation: BMC Clinical Pharmacology 2012 12:7

    The Erratum to this article has been published in BMC Clinical Pharmacology 2012 12:14

  8. Acute paracetamol poisoning is a rapidly increasing problem in Sri Lanka. The antidotes are expensive and yet no health economic evaluation has been done on the therapy for acute paracetamol poisoning in the d...

    Authors: S M D K Ganga Senarathna, Shalini Sri Ranganathan, Nick Buckley and Rohini Fernandopulle
    Citation: BMC Clinical Pharmacology 2012 12:6
  9. Addressing the problem of preventable drug related morbidity (PDRM) in primary care is a challenge for health care systems internationally. The increasing implementation of clinical information systems in the ...

    Authors: Tobias Dreischulte, Aileen M Grant, Colin McCowan, John J McAnaw and Bruce Guthrie
    Citation: BMC Clinical Pharmacology 2012 12:5
  10. Contrast-induced nephropathy is a common complication of contrast administration in patients with chronic kidney disease and diabetes. Its pathophysiology is not well understood; similarly the role of intraven...

    Authors: Euan A Sandilands, Sharon Cameron, Frances Paterson, Sam Donaldson, Lesley Briody, Jane Crowe, Julie Donnelly, Adrian Thompson, Neil R Johnston, Ivor Mackenzie, Neal Uren, Jane Goddard, David J Webb, Ian L Megson, Nicholas Bateman and Michael Eddleston
    Citation: BMC Clinical Pharmacology 2012 12:3
  11. Therapeutic drug monitoring of immunosuppressive drugs in organ-transplanted patients is crucial to prevent intoxication or transplant rejection due to inadequate dosage. The commonly used immunoassays have be...

    Authors: Armin Buchwald, Karl Winkler and Thomas Epting
    Citation: BMC Clinical Pharmacology 2012 12:2
  12. We aimed to explore relations between symptomatic remission and functionality evaluation in schizophrenia patients treated with paliperidone extended-release (ER), as seen in a normal day-to-day practice, usin...

    Authors: Min-Wei Huang, Tsung-Tsair Yang, Po-Ren Ten, Po-Wen Su, Bo-Jian Wu, Chin-Hong Chan, Tsuo-Hung Lan, I-Chao Liu, Wei-Cheh Chiu, Chun-Ying Li, Kuo-Sheng Cheng and Yu-Chi Yeh
    Citation: BMC Clinical Pharmacology 2012 12:1
  13. Drospirenone/ethinyl-estradiol is an oral contraceptive (OC) that possesses unique antimineralocorticoid activity. It is conjectured that drospirenone, taken alone or concomitantly with spironolactone, may be ...

    Authors: Steven T Bird, Salvatore R Pepe, Mahyar Etminan, Xinyue Liu, James M Brophy and Joseph AC Delaney
    Citation: BMC Clinical Pharmacology 2011 11:23
  14. Clinical effects and outcomes of a single dose etomidate prior to intubation in the intensive care setting is controversial. The aim of this study is to evaluate the association of a single dose effect of etom...

    Authors: Antoine J Cherfan, Hani M Tamim, Abdulrahman AlJumah, Asgar H Rishu, Abdulmajeed Al-Abdulkareem, Bandar A Al Knawy, Ali Hajeer, Waleed Tamimi, Riette Brits and Yaseen M Arabi
    Citation: BMC Clinical Pharmacology 2011 11:22
  15. This study aimed at describing the type and dosage of psychopharmaceuticals dispensed to patients with psychiatric disorders and to assess the percentage of patients treated with antipsychotics and antidepress...

    Authors: Stefano Bianchi, Erica Bianchini and Paola Scanavacca
    Citation: BMC Clinical Pharmacology 2011 11:21
  16. Mandatory generic substitution (GS) was introduced in Finland at the beginning of April 2003. However, individual patients or physicians may forbid the substitution. GS was a significant change for Finnish med...

    Authors: Reeta Heikkilä, Pekka Mäntyselkä and Riitta Ahonen
    Citation: BMC Clinical Pharmacology 2011 11:20
  17. The choices for self-medication in Hong Kong are much diversified, including western and Chinese medicines and food supplements. This study was to examine Hong Kong public knowledge, attitudes and behaviours r...

    Authors: Joyce H You, Fiona Y Wong, Frank W Chan, Eliza L Wong and Eng-kiong Yeoh
    Citation: BMC Clinical Pharmacology 2011 11:19
  18. Misuse of antimicrobials (AMs) and antimicrobial resistance (AMR) are global concerns. The present study evaluated knowledge, attitudes and practices about AMR and AM prescribing among medical doctors in two l...

    Authors: Coralith García, Liz P Llamocca, Krystel García, Aimee Jiménez, Frine Samalvides, Eduardo Gotuzzo and Jan Jacobs
    Citation: BMC Clinical Pharmacology 2011 11:18
  19. Panitumumab is a fully human antibody against the epidermal growth factor receptor that is indicated for the treatment of metastatic colorectal cancer (mCRC) after disease progression on standard chemotherapy....

    Authors: Dohan Weeraratne, Alin Chen, Jason J Pennucci, Chi-Yuan Wu, Kathy Zhang, Jacqueline Wright, Juan José Pérez-Ruixo, Bing-Bing Yang, Arunan Kaliyaperumal, Shalini Gupta, Steven J Swanson, Narendra Chirmule and Marta Starcevic
    Citation: BMC Clinical Pharmacology 2011 11:17
  20. According to the World Health Organization (WHO) the cost of adverse drug reactions (ADRs) in the general population is high and under-reporting by health professionals is a well-recognized problem. Another wa...

    Authors: Andreas Vilhelmsson, Tommy Svensson, Anna Meeuwisse and Anders Carlsten
    Citation: BMC Clinical Pharmacology 2011 11:16
  21. Spontaneous reporting of adverse drug reactions (ADRs) is an important method for pharmacovigilance, but under-reporting and poor quality of reports are major limitations. The aim of this study was to evaluate...

    Authors: Marie-Louise Johansson, Staffan Hägg and Susanna M Wallerstedt
    Citation: BMC Clinical Pharmacology 2011 11:14
  22. In many but not in all neuropsychological studies buprenorphine-treated opioid-dependent patients have shown fewer cognitive deficits than patients treated with methadone. In order to examine if hypothesized c...

    Authors: Pekka Rapeli, Carola Fabritius, Hely Kalska and Hannu Alho
    Citation: BMC Clinical Pharmacology 2011 11:13
  23. The effect of statin therapy on mortality in critically ill patients is controversial, with some studies suggesting a benefit and others suggesting no benefit or even potential harm. The objective of this stud...

    Authors: Shmeylan A Al Harbi, Hani M Tamim and Yaseen M Arabi
    Citation: BMC Clinical Pharmacology 2011 11:12
  24. The study aimed to investigate the pharmacokinetics of intravenous ciprofloxacin and the adequacy of 400 mg every 12 hours in critically ill Intensive Care Unit (ICU) patients on continuous veno-venous haemodi...

    Authors: Almath M Spooner, Catherine Deegan, Deirdre M D'Arcy, Caitriona M Gowing, Maria B Donnelly and Owen I Corrigan
    Citation: BMC Clinical Pharmacology 2011 11:11
  25. The lipid fraction of cell membranes consists of polyunsaturated fatty acids (PUFAS), and chronic alcohol use alters it, modifying its permeability, what might contribute for the dysfunctional metabolism obser...

    Authors: Marina N Fogaça, Ruth F Santos-Galduróz, Jaqueline K Eserian and José Carlos F Galduróz
    Citation: BMC Clinical Pharmacology 2011 11:10
  26. One of the most critical problems about antimicrobial therapy is the increasing resistance to antibiotics. Previous studies have shown that there is a direct relation between erroneous prescription, dosage, ro...

    Authors: Jorge A Diaz, Edelberto Silva, Maria J Arias and María Garzón
    Citation: BMC Clinical Pharmacology 2011 11:9
  27. Ibuprofen treatment of patent ductus arteriosus (PDA) has been shown to be as effective as indomethacin in small randomized controlled trials, with possibly fewer adverse effects. However, adverse renal effect...

    Authors: Alla Kushnir and Joaquim MB Pinheiro
    Citation: BMC Clinical Pharmacology 2011 11:8
  28. Roflumilast is an oral, selective phosphodiesterase 4 inhibitor with anti-inflammatory effects in chronic obstructive pulmonary disease (COPD). The addition of roflumilast to long-acting bronchodilators improv...

    Authors: Christian de Mey, Nassr Nassr and Gezim Lahu
    Citation: BMC Clinical Pharmacology 2011 11:7
  29. In the last decades, the provision of pharmaceutical care by community pharmacists has developed in OECD countries. These developments involved significant changes in professional practices and organization of...

    Authors: Clémence Perraudin, Françoise Brion, Olivier Bourdon and Nathalie Pelletier-Fleury
    Citation: BMC Clinical Pharmacology 2011 11:6
  30. Thiazolidinediones (TZDs), rosiglitazone (RGZ) and pioglitazone (PGZ) are widely used as hypoglycemic drugs in patients with type 2 diabetes mellitus. The aim of our study was to investigate the profile of adv...

    Authors: Stephanie Berthet, Pascale Olivier, Jean-Louis Montastruc and Maryse Lapeyre-Mestre
    Citation: BMC Clinical Pharmacology 2011 11:5
  31. Zibotentan (ZD4054) is a specific endothelin A (ETA) receptor antagonist being investigated for the treatment of prostate cancer. As zibotentan is eliminated by renal and metabolic routes, clearance may be reduce...

    Authors: Helen Tomkinson, John Kemp, Stuart Oliver, Helen Swaisland, Maria Taboada and Thomas Morris
    Citation: BMC Clinical Pharmacology 2011 11:3
  32. Constipation and diarrhoea are common complaints and often reported as adverse drug reactions. This study aimed at finding associations between drugs and constipation and diarrhoea in a general population.

    Authors: Gunvor S Fosnes, Stian Lydersen and Per G Farup
    Citation: BMC Clinical Pharmacology 2011 11:2
  33. Phenoxodiol is a novel isoflavone currently being studied in clinical trials for the treatment of cancer. This study reports the pharmacokinetics of phenoxodiol in patients with cancer.

    Authors: Jan B Howes, Paul L de Souza, Leanne West, Li Jiu Huang and Laurence G Howes
    Citation: BMC Clinical Pharmacology 2011 11:1
  34. An increase in the use of drugs and polypharmacy have been displayed over time in spite of the fact that polypharmacy represents a well known risk factor as regards patients' health due to the adverse drug rea...

    Authors: Bo Hovstadius, Karl Hovstadius, Bengt Åstrand and Göran Petersson
    Citation: BMC Clinical Pharmacology 2010 10:16
  35. Mandatory generic substitution (GS) was introduced in Finland on 1 April 2003. The aim of this study was to explore and compare the impacts of GS on the activities of pharmaceutical companies representing main...

    Authors: Johanna Timonen, Marina Bengtström, Pekka Karttunen and Riitta Ahonen
    Citation: BMC Clinical Pharmacology 2010 10:15
  36. Somatropin is recombinant human growth hormone (GH) used for the treatment of growth failure in children and GH deficiency in adults. Two concentrations of a liquid formulation have been developed: 5.83 and 8....

    Authors: Bernd Liedert, Ulf Forssmann, Peter Wolna, Michaela Golob and Andreas Kovar
    Citation: BMC Clinical Pharmacology 2010 10:14
  37. Alpha1-antitrypsin (AAT) deficiency is characterized by low blood levels of alpha1-proteinase inhibitor (alpha1-PI) and may lead to emphysema. Alpha1-PI protects pulmonary tissue from damage caused by the action ...

    Authors: James M Stocks, Mark L Brantly, Laurene Wang-Smith, Michael A Campos, Kenneth R Chapman, Friedrich Kueppers, Robert A Sandhaus, Charlie Strange and Gerard Turino
    Citation: BMC Clinical Pharmacology 2010 10:13
  38. Two randomised 12-week, double-blind, parallel-group, multicenter studies comparing oxycodone PR/naloxone PR and oxycodone PR alone on symptoms of opioid-induced bowel dysfunction in patients with moderate/sev...

    Authors: Oliver Löwenstein, Petra Leyendecker, Eberhard A Lux, Mark Blagden, Karen H Simpson, Michael Hopp, Björn Bosse and Karen Reimer
    Citation: BMC Clinical Pharmacology 2010 10:12
  39. The efficiency of antiretroviral therapy (ART) depends on a near perfect level of patients' adherence. The level of adherence of adults HIV-infected patients treated in the HIV/AIDS health care centres of the ...

    Authors: Yao Potchoo, Kpatcha Tchamdja, Agnon Balogou, Vincent P Pitche, Innocent P Guissou and Etienne K Kassang
    Citation: BMC Clinical Pharmacology 2010 10:11
  40. Ibuprofen and paracetamol differ in their mode of action and related therapeutic effects, suggesting that combined administration may offer improved analgesia. Reported here are the results of two studies on t...

    Authors: Trevor Tanner, Sue Aspley, Andrew Munn and Tracy Thomas
    Citation: BMC Clinical Pharmacology 2010 10:10
  41. In spite of recent advances in post-operative pain relief, pain following orthopedic surgery remains an ongoing challenge for clinicians. We examined whether a well known and frequently prescribed homeopathic ...

    Authors: Shepherd R Singer, Michal Amit-Kohn, Samuel Weiss, Jonathan Rosenblum, Guy Maoz, Noah Samuels, Esther Lukasiewicz, Laurence Freedman, Ora Paltiel, Menachem Itzchaki, Meir Niska and Menachem Oberbaum
    Citation: BMC Clinical Pharmacology 2010 10:9
  42. Safety culture assessment is increasingly recognized as an important component in healthcare quality improvement, also in pharmacies. One of the most commonly used and rigorously validated tools to measure saf...

    Authors: Annika Nordén-Hägg, J Bryan Sexton, Sofia Kälvemark-Sporrong, Lena Ring and Åsa Kettis-Lindblad
    Citation: BMC Clinical Pharmacology 2010 10:8
  43. Pentosan polysulfate sodium (pentosan) is a semi-synthetic drug manufactured from beech-wood hemicellulose by sulfate esterification of the xylopyranose hydroxyl groups. From in vitro and animal model studies,...

    Authors: Kenji Kumagai, Susumu Shirabe, Noriaki Miyata, Masakazu Murata, Atsushi Yamauchi, Yasuhumi Kataoka and Masami Niwa
    Citation: BMC Clinical Pharmacology 2010 10:7
  44. Distalgesic, the prescription-only analgesic compound of paracetamol (325 mg) and dextropropoxyphene (32.5 mg) known as co-proxamol in the UK, was withdrawn from the Irish market as of January 2006. This study...

    Authors: Paul Corcoran, Udo Reulbach, Helen S Keeley, Ivan J Perry, Keith Hawton and Ella Arensman
    Citation: BMC Clinical Pharmacology 2010 10:6
  45. New drugs are generally claimed to represent a therapeutic innovation. However, scientific evidence of a substantial clinical advantage is often lacking. This may be the result of using inadequate control grou...

    Authors: Isabel Püntmann, Norbert Schmacke, Arne Melander, Gunnar Lindberg and Bernd Mühlbauer
    Citation: BMC Clinical Pharmacology 2010 10:5
  46. Adherence to prescribing guidelines varies between primary health care units. The aim of the present study was to investigate correlations between characteristics of primary health care units and adherence to ...

    Authors: Daniel Carlzon, Lena Gustafsson, Anna L Eriksson, Karin Rignér, Anders Sundström and Susanna M Wallerstedt
    Citation: BMC Clinical Pharmacology 2010 10:4