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  1. Research article

    Statin therapy in critical illness: an international survey of intensive care physicians’ opinions, attitudes and practice

    Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ f...

    Manu Shankar-Hari, Peter S Kruger, Stefania Di Gangi, Damon C Scales, Gavin D Perkins, Danny F McAuley and Marius Terblanche

    BMC Clinical Pharmacology 2012 12:13

    Published on: 28 June 2012

  2. Research article

    Data for drugs available through low-cost prescription drug programs are available through pharmacy benefit manager and claims data

    Observational data are increasingly being used for pharmacoepidemiological, health services and clinical effectiveness research. Since pharmacies first introduced low-cost prescription programs (LCPP), researc...

    Vivienne J Zhu, Anne Belsito, Wanzhu Tu and J Marc Overhage

    BMC Clinical Pharmacology 2012 12:12

    Published on: 22 June 2012

  3. Research article

    Adherence to medication for the treatment of psychosis: rates and risk factors in an Ethiopian population

    Medication-taking behavior, specifically non-adherence, is significantly associated with treatment outcome and is a major cause of relapse in the treatment of psychotic disorders. Non-adherence can be multifac...

    Menna Alene, Michael D Wiese, Mulugeta T Angamo, Beata V Bajorek, Elias A Yesuf and Nasir Tajure Wabe

    BMC Clinical Pharmacology 2012 12:10

    Published on: 18 June 2012

  4. Research article

    Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial

    Consistent with its effect on gastric emptying, exenatide, an injectable treatment for type 2 diabetes, may slow the absorption rate of concomitantly administered oral drugs resulting in a decrease in maximum ...

    Prajakti A Kothare, Mary E Seger, Justin Northrup, Kenneth Mace, Malcolm I Mitchell and Helle Linnebjerg

    BMC Clinical Pharmacology 2012 12:8

    Published on: 19 March 2012

  5. Research article

    Adverse drug reactions to antiretroviral therapy (ARVs): incidence, type and risk factors in Nigeria

    Data on adverse drug reactions (ADRs) related to antiretroviral (ARV) use in public health practice are few indicating the need for ART safety surveillance in clinical care.

    George I Eluwa, Titilope Badru and Kesiena J Akpoigbe

    BMC Clinical Pharmacology 2012 12:7

    Published on: 27 February 2012

    The Erratum to this article has been published in BMC Clinical Pharmacology 2012 12:14

  6. Research article

    A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka

    Acute paracetamol poisoning is a rapidly increasing problem in Sri Lanka. The antidotes are expensive and yet no health economic evaluation has been done on the therapy for acute paracetamol poisoning in the d...

    S M D K Ganga Senarathna, Shalini Sri Ranganathan, Nick Buckley and Rohini Fernandopulle

    BMC Clinical Pharmacology 2012 12:6

    Published on: 22 February 2012

  7. Research article

    Quality and safety of medication use in primary care: consensus validation of a new set of explicit medication assessment criteria and prioritisation of topics for improvement

    Addressing the problem of preventable drug related morbidity (PDRM) in primary care is a challenge for health care systems internationally. The increasing implementation of clinical information systems in the ...

    Tobias Dreischulte, Aileen M Grant, Colin McCowan, John J McAnaw and Bruce Guthrie

    BMC Clinical Pharmacology 2012 12:5

    Published on: 8 February 2012

  8. Research article

    Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects

    High dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at ...

    Howard A Smithline, Michael Donnino and David J Greenblatt

    BMC Clinical Pharmacology 2012 12:4

    Published on: 4 February 2012

  9. Study protocol

    Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol

    Contrast-induced nephropathy is a common complication of contrast administration in patients with chronic kidney disease and diabetes. Its pathophysiology is not well understood; similarly the role of intraven...

    Euan A Sandilands, Sharon Cameron, Frances Paterson, Sam Donaldson, Lesley Briody, Jane Crowe, Julie Donnelly, Adrian Thompson, Neil R Johnston, Ivor Mackenzie, Neal Uren, Jane Goddard, David J Webb, Ian L Megson, Nicholas Bateman and Michael Eddleston

    BMC Clinical Pharmacology 2012 12:3

    Published on: 3 February 2012

  10. Research article

    Effects of paliperidone extended release on the symptoms and functioning of schizophrenia

    We aimed to explore relations between symptomatic remission and functionality evaluation in schizophrenia patients treated with paliperidone extended-release (ER), as seen in a normal day-to-day practice, usin...

    Min-Wei Huang, Tsung-Tsair Yang, Po-Ren Ten, Po-Wen Su, Bo-Jian Wu, Chin-Hong Chan, Tsuo-Hung Lan, I-Chao Liu, Wei-Cheh Chiu, Chun-Ying Li, Kuo-Sheng Cheng and Yu-Chi Yeh

    BMC Clinical Pharmacology 2012 12:1

    Published on: 6 January 2012

  11. Research article

    Etomidate and mortality in cirrhotic patients with septic shock

    Clinical effects and outcomes of a single dose etomidate prior to intubation in the intensive care setting is controversial. The aim of this study is to evaluate the association of a single dose effect of etom...

    Antoine J Cherfan, Hani M Tamim, Abdulrahman AlJumah, Asgar H Rishu, Abdulmajeed Al-Abdulkareem, Bandar A Al Knawy, Ali Hajeer, Waleed Tamimi, Riette Brits and Yaseen M Arabi

    BMC Clinical Pharmacology 2011 11:22

    Published on: 30 December 2011

  12. Research article

    The association between drospirenone and hyperkalemia: a comparative-safety study

    Drospirenone/ethinyl-estradiol is an oral contraceptive (OC) that possesses unique antimineralocorticoid activity. It is conjectured that drospirenone, taken alone or concomitantly with spironolactone, may be ...

    Steven T Bird, Salvatore R Pepe, Mahyar Etminan, Xinyue Liu, James M Brophy and Joseph AC Delaney

    BMC Clinical Pharmacology 2011 11:23

    Published on: 30 December 2011

  13. Research article

    Price, familiarity, and availability determine the choice of drug - a population-based survey five years after generic substitution was introduced in Finland

    Mandatory generic substitution (GS) was introduced in Finland at the beginning of April 2003. However, individual patients or physicians may forbid the substitution. GS was a significant change for Finnish med...

    Reeta Heikkilä, Pekka Mäntyselkä and Riitta Ahonen

    BMC Clinical Pharmacology 2011 11:20

    Published on: 15 December 2011

  14. Research article

    Knowledge, attitudes and practice survey about antimicrobial resistance and prescribing among physicians in a hospital setting in Lima, Peru

    Misuse of antimicrobials (AMs) and antimicrobial resistance (AMR) are global concerns. The present study evaluated knowledge, attitudes and practices about AMR and AM prescribing among medical doctors in two l...

    Coralith García, Liz P Llamocca, Krystel García, Aimee Jiménez, Frine Samalvides, Eduardo Gotuzzo and Jan Jacobs

    BMC Clinical Pharmacology 2011 11:18

    Published on: 15 November 2011

  15. Research article

    Immunogenicity of panitumumab in combination chemotherapy clinical trials

    Panitumumab is a fully human antibody against the epidermal growth factor receptor that is indicated for the treatment of metastatic colorectal cancer (mCRC) after disease progression on standard chemotherapy....

    Dohan Weeraratne, Alin Chen, Jason J Pennucci, Chi-Yuan Wu, Kathy Zhang, Jacqueline Wright, Juan José Pérez-Ruixo, Bing-Bing Yang, Arunan Kaliyaperumal, Shalini Gupta, Steven J Swanson, Narendra Chirmule and Marta Starcevic

    BMC Clinical Pharmacology 2011 11:17

    Published on: 9 November 2011

  16. Research article

    What can we learn from consumer reports on psychiatric adverse drug reactions with antidepressant medication? Experiences from reports to a consumer association

    According to the World Health Organization (WHO) the cost of adverse drug reactions (ADRs) in the general population is high and under-reporting by health professionals is a well-recognized problem. Another wa...

    Andreas Vilhelmsson, Tommy Svensson, Anna Meeuwisse and Anders Carlsten

    BMC Clinical Pharmacology 2011 11:16

    Published on: 25 October 2011

  17. Research article

    Impact of information letters on the reporting rate of adverse drug reactions and the quality of the reports: a randomized controlled study

    Spontaneous reporting of adverse drug reactions (ADRs) is an important method for pharmacovigilance, but under-reporting and poor quality of reports are major limitations. The aim of this study was to evaluate...

    Marie-Louise Johansson, Staffan Hägg and Susanna M Wallerstedt

    BMC Clinical Pharmacology 2011 11:14

    Published on: 7 September 2011

  18. Research article

    Cognitive functioning in opioid-dependent patients treated with buprenorphine, methadone, and other psychoactive medications: stability and correlates

    In many but not in all neuropsychological studies buprenorphine-treated opioid-dependent patients have shown fewer cognitive deficits than patients treated with methadone. In order to examine if hypothesized c...

    Pekka Rapeli, Carola Fabritius, Hely Kalska and Hannu Alho

    BMC Clinical Pharmacology 2011 11:13

    Published on: 21 August 2011

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