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Table 2 Urinary excretion of toxic metals in Phase 1, at baseline, after 1st dose, and after 9thdose, in mcg/g creatinine.

From: Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A - Medical results

Element Baseline 1stDose 9thDose 1stdose vs. baseline 9thdose vs. baseline
Pb 1.3 +/- 2.3 10. +/- 19. 9.2 +/- 7.8 713%*** 638%***
Sn 2.3 +/- 3.4 8.0 +/- 13 9.7 +/- 24 241%*** 314%*
Bi 0.18 +/- 0.45 0.47 +/- 1.4 0.41 +/- 1.0 161%+ 128%*
U 0.015 +/- .04 0.036 +/- .09 0.031 +/- .1 104% 111%
Hg 0.86 +/- .92 1.5 +/- 1.4 0.97 +/- 0.88 70%** 13%
Tl 0.15 +/- 0.12 0.25 +/- 0.18 0.21 +/- 0.19 67%*** 42%**
Sb 0.10 +/- 0.10 0.15 +/- 0.19 0.14 +/- 0.20 49%* 42%+
W 0.39 +/- 0.29 0.59 +/- 0.63 0.46 +/- 0.50 51%** 18%*
Al 16 +/- 21 18 +/- 23 19 +/- 33 11% 21%
Ni 6.7 +/- 5.1 5.5 +/- 3.6 7.6 +/- 4.3 -18%* 12%
Cd 0.38 +/- 0.24 0.40 +/- 0.24 0.33 +/- 0.23 5% -14%
As 32 +/- 20 32 +/- 18 25 +/- 18 0% -19%*
creatinine 94 +/- 52 62 +/- 39 80 +/- 43 -34%*** -15%*
  1. + P < 0.1
  2. *P < 0.05
  3. ** P < 0.01
  4. *** P < 0.001
  5. Creatinine values have units of mg/dl. N = 63. The metals are listed in approximate order of effect of DMSA on excretion. Significant results are highlighted in bold font.