Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A - Medical results

Table 2 Urinary excretion of toxic metals in Phase 1, at baseline, after 1^st dose, and after 9^thdose, in mcg/g creatinine.

Element	Baseline	1^stDose	9^thDose	1^stdose vs. baseline	9^thdose vs. baseline
Pb	1.3 +/- 2.3	10. +/- 19.	9.2 +/- 7.8	713%***	638%***
Sn	2.3 +/- 3.4	8.0 +/- 13	9.7 +/- 24	241%***	314%*
Bi	0.18 +/- 0.45	0.47 +/- 1.4	0.41 +/- 1.0	161%+	128%*
U	0.015 +/- .04	0.036 +/- .09	0.031 +/- .1	104%	111%
Hg	0.86 +/- .92	1.5 +/- 1.4	0.97 +/- 0.88	70%**	13%
Tl	0.15 +/- 0.12	0.25 +/- 0.18	0.21 +/- 0.19	67%***	42%**
Sb	0.10 +/- 0.10	0.15 +/- 0.19	0.14 +/- 0.20	49%*	42%+
W	0.39 +/- 0.29	0.59 +/- 0.63	0.46 +/- 0.50	51%**	18%*
Al	16 +/- 21	18 +/- 23	19 +/- 33	11%	21%
Ni	6.7 +/- 5.1	5.5 +/- 3.6	7.6 +/- 4.3	-18%*	12%
Cd	0.38 +/- 0.24	0.40 +/- 0.24	0.33 +/- 0.23	5%	-14%
As	32 +/- 20	32 +/- 18	25 +/- 18	0%	-19%*
creatinine	94 +/- 52	62 +/- 39	80 +/- 43	-34%***	-15%*

+ P < 0.1
*P < 0.05
** P < 0.01
*** P < 0.001
Creatinine values have units of mg/dl. N = 63. The metals are listed in approximate order of effect of DMSA on excretion. Significant results are highlighted in bold font.