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Table 3 Pharmacokinetic profile

From: Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteoporosis with oral calcitonin

 

Part 1

n = 42

Morning dosing

Part 2

n = 20

Pre-dinner dosing

Part 3

n = 19

Evening dosing

Cmax (pg/ml)

45.1 (39.1–52.0)

44.7 (31.8–62.9)

23.8 (16.9–33.5)

Tmax (minutes)

30 (15–30)

30 (15–30)

30 (30–33.8)

AUC0–4 hrs

30.6 (27.2–34.4)

36.3 (28.6–46.1)

28.1 (21.6–36.6)

  1. AUC0–4 hrs and Cmax is given as geometric mean (mean ± 1SEM range) and Tmax as median (25–75 percentile)
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BMC Clinical Pharmacology

ISSN: 1472-6904