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Table 1 described the study design in the 3 parts with the time of meal and dosing of oral calcitonin.

From: Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteoporosis with oral calcitonin

Study Design: Timing of Dosing and Meal Intake

 

08:00

09:00

13:00

17:00

18:00

22:00

08:00

09:00

13:00

17:00

18:00

22:00

Part 1 Morning Dosing

Dose

Meal

Meal

-

Meal

-

End

x

x

x

x

x

Part 2 Pre-dinner Dosing

x

x

Meal

Dose

Meal

-

-

Meal

Meal

End

x

x

Part 3 Evening Dosing

x

x

x

x

Meal

Dose

-

Meal

Meal

-

Meal

End

  1. (-) Denotes study period with no action. (X) Denotes not part of study period.