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Table 2 Comedications among OST patients within the last 24 h before testing

From: Methadone vs. buprenorphine/naloxone during early opioid substitution treatment: a naturalistic comparison of cognitive performance relative to healthy controls

Medications used within 24 hours of test

Methadone-treated patients

(n = 16)

 

Buprenorphine/Naloxone- treated patients

(n = 17)

 
 

Proportion of patients

Dose, range

Proportion of patients

Dose, range

Antidepressives (any)

44 %

 

35'%

 

   Essitalopram

6%

5 mg

  

   Citalopram

6 %

20 mg

  

   Doxepine

  

12%

75 – 100 mg

   Fluoxetine

13%

20 – 30 mg

  

   Mirtazapine

13%

15 mg

  

   Paroxetine

  

6%

50 mg

   Sertraline

6%

50 mg

12%

50 mg

   Venlaflaxine

  

12%

75 mg

Anxiolytics, sedatives and hypnotics:

    

Benzodiazepines (any)

81 %

 

76%

 

   Diazepam

38%

5–20 mg

29%

15 -40 mg

   Oxazepam

44%

45 – 120 mg

47%

30 – 90 mg

   Nitratzepam*

6%

20 mg

  

   Tematzepam *

19%

20 mg

12%

20 mg

Non-benzodiazepine hypnotics (any)

25%

 

35%

 

   Zolpidem *

6%

10 mg

6%

15 mg

   Zopiclone *

19%

7.5 – 15 mg

24%

7.5 – 15 mg

Neuroleptics † (any)

25%

 

18%

 

   Chlorpromazine

  

6%

50 mg

   Flupenthixole

6%

0.5 mg

  

   Levomepromazine

6%

150 mg

6%

100 mg

   Quetiapine

13%

50–100 mg

6%

300 mg

Opioid withdrawal symptom or pain relievers (any)

69 %

 

53%

 

   Hydroxyzine

38%

25–200 mg

24%

75 – 300 mg

   Ibuprofeine

13%

600– 2400 mg

6%

400 mg

   Lofexidine

6%

0.2mg

18%

0.2 – 0.6 mg

   Metoclopramide

6%

10 mg

  

   Naproxen

6%

500 mg

6%

500 mg

   Propranol

6%

20 mg

  

   Valproate

13%

500 – 1000 mg

24%

500 – 1000 mg

None medication

13%

 

12%

 
  1. * Used as a hypnotic the night before testing.
  2. † Used with anxiolytic indications