BMC Clinical Pharmacology

Table 3 Mean (SD) of the dose-normalized pharmacokinetic parameters after administration of OROS^® hydromorphone 8, 16, 32, and 64 mg (n = 31)

From: Pharmacokinetic investigation of dose proportionality with a 24-hour controlled-release formulation of hydromorphone

Parameter	8 mg	16 mg	32 mg	64 mg
C_max, ng/mL/mg	0.116 (0.127)	0.106 (0.049)	0.102 (0.043)	0.103 (0.027)
AUC_0–48, ng·hr/mL/mg	2.26 (0.72)	2.28 (0.71)	2.26 (0.76)	2.44 (0.48)
AUC_0–∞, ng·hr/mL/mg	2.44 (0.74)	2.55 (0.86)	2.51 (0.93)	2.79 (0.55)

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