Figure 3

Comparison of Isoflurane_S early time experimental data (squares) and model predictions (line) for the one adipose compartment (N = 1) PBPK model for adipose perfusion rates (F_T) varying from 0 to 0.066 l/kg/min. The optimal value of σ (= 3) is used. The top panel shows an absolute plot of the (end tidal partial pressure)/(inspired partial pressure) (= P/P_insp) versus time. The bottom panels show semi log plots of 1 - P/P_insp during the 30 minute uptake period (left) and P/Pinsp (right) during the 150 minute washout period.