Table 3 Ramipril adjustable PBPK parameters: 1) intrinsic liver clearance (Clint_L); 2) intrinsic kidney clearance (Clint_K; 3) the fraction of the liver ramipril clearance that is converted to systemic ramiprilat. The "average weighted residual error'' of the PBPK model plasma ramiprilat following either IV or oral ramipril is listed in the last two columns.
From: Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat
Subject | Clint_L (l/min) | Clint_K (l/min) | Fraction to ramiprilat | IV Ramipril Ave. Error | Oral Ramipril Ave. Error |
|---|---|---|---|---|---|
1 | 4.8 | 1.2 | 0.1 | 0.2 | 0.23 |
3 | 1 | 1.5 | 0.32 | 0.17 | 0.25 |
4 | 3.6 | 0.9 | 0.4 | 0.23 | 0.27 |
5 | 2 | 2 | 0.0 | 0.17 | Poor fit |
6 | 3 | 1 | 0.25 | 0.23 | 0.28 |
7 | 4 | 1 | 0.2 | 0.14 | 0.14 |
8 | 5.5 | 0 | 0.4 | 0.13 | 0.22 |
9 | 3.48 | 0.52 | 0.2 | 0.12 | 0.38 |
10 | 3.5 | 1.5 | 0.4 | 0.30 | 0.34 |
11 | 2.8 | 1.2 | 0.3 | 0.23 | 0.14 |
12 | 6.16 | 0.84 | 0.2 | 0.13 | 0.2 |
Ave (SD) | 3.62 (1.5) | 1.06 (0.53) | 0.25 (0.13) | 0.19 (0.057) | 0.24 (0.077) |