Table 2 Ramiprilat Adjustable PBPK Parameters: Intrinsic renal clearance, ACE plasma concentration, and liver and kidney cell membrane permeability coefficient. The "average weighted residual error" of the PBPK model for the IV ramiprilat input is listed in the last column.
From: Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat
Subject | Renal Clear. Clu (l/min) | ACEplasma (nM) | Membrane Permeability (Ps min-1) | IV Ramiprilat Ave. Error | |
|---|---|---|---|---|---|
| Â | Â | Â | Liver | Kidney | Â |
1 | 0.55 | 1.5 | 0.015 | 0.0003 | 0.11 |
3 | 0.4 | 2.35 | 0.007 | 0.0015 | 0.10 |
4 | 0.4 | 1.65 | 0.018 | 0.001 | 0.17 |
5 | 0.55 | 1.13 | 0.01 | 0.0006 | 0.16 |
6 | 0.4 | 1.25 | 0.015 | 0.002 | 0.27 |
7 | 0.7 | 2.25 | 0.01 | 0.0006 | 0.18 |
8 | 0.4 | 2.9 | 0.01 | 0.0006 | 0.11 |
9 | 0.37 | 1.75 | 0.008 | 0.0003 | 0.32 |
10 | 0.45 | 1.45 | 0.015 | 0.002 | 0.13 |
11 | 0.45 | 1.4 | 0.01 | 0.0003 | 0.30 |
12 | 0.4 | 2.25 | 0.006 | 0.0003 | 0.14 |
Ave (SD) | 0.46 (0.10) | 1.81 (0.55) | 0.011 (0.0039) | 0.00086 (0.00067) | 0.18 (0.08) |