Table 4 Intestinal absorption parameters for oral ramipril: 1) the major ramipril absorption component (gamma function, A, a, and T); 2) a slow, long ramipril component (Aslow); and 3) direct intestinal conversion and absorption of ramiprilat (gamma function, AR, a and T). The total oral dose is 2.5 mg (6010 nanomoles). The total amount absorbed = A + Aslow+ AR.
From: Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat
Subject | Ramipril- Major component | Slow absorp. Amount Aslow (nmole) | Ramprilat Amount AR (nmole) | Total Absorption (nmole) | ||
|---|---|---|---|---|---|---|
| Â | Amount (A) (nmole) | Time const. (T) (min) | Gamma (a) | Â | Â | Â |
1 | 2500 | 90 | 3 | 787 | 200 | 3487 |
3 | 1200 | 53 | 9 | 367 | 60 | 1627 |
4 | 1600 | 45 | 8 | 432 | 30 | 2062 |
5 | 1400 | 48 | 3.2 | 0 | 100 | 1500 |
6 | 1800 | 35 | 3 | 0 | 100 | 1900 |
7 | 800 | 25 | 3 | 320 | 41 | 1161 |
8 | 2100 | 70 | 2 | 756 | 200 | 3056 |
9 | 2200 | 65 | 6 | 0 | 100 | 2300 |
10 | 1800 | 60 | 5.5 | 0 | 100 | 1900 |
11 | 1100 | 35 | 3 | 346 | 100 | 1546 |
12 | 2700 | 80 | 4 | 0 | 400 | 3100 |
Ave (SD) | 1745 (597) | 55.1 (20.1) | 4.4 (2.3) | 273 (301) | 130 (105) | 2149 (755) |