Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat

Table 1 Standard human population PBPK organ parameters (not varied).

Organ	Weight (Kg)	ECF water(L)	Flow (L/min)	ACE Tiss/Plasma	Ramiprialat Ps (min^-1)	Ramiprilat fu_cell	Ramipril Ps (min^-1)	Ramipril fu_cell
Blood	5.5	2.68345		0.52	0	----
liver	1.8	0.2898	0.45	1.37	Adjustable	1	infinite	0.1
portal	1.5	0.351	1.125	2.0	0	----	0.05	0.5
muscle	26	3.042	0.585	1.0	0	----	0.05	0.5
kidney	0.31	0.04092	1.24	5.62	Adjustable	10	infinite	0.01
brain	1.4	0	0.784	0.8	0	----	0.05	0.5
heart	0.33	0.066	0.264	1.7	0	----	0.05	0.5
lung	0.536	0.08576	5.6184	34	0	----	0.05	0.5
skin	2.6	1.092	0.26	3.51	0	----	0.05	0.5
tendon	3	2.55	0.03	7.23	0	----	0.05	0.5
other	5.524	3.75632	0.1104	5.79	0	----	0.05	0.5
bone	4	0	0	0	0	----	0	0.5
adipose	17.5	3.5	0.7385	6.81	0	----	0.05	0.5
Total	70	17.4572	5.5877