Figure 20From: Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilatTop: five day plasma ramiprilat for either once per day 2.5 mg oral ramipril (black) or twice per day 1.25 mg oral ramipril (red). Bottom: Fraction of C site (left) or N site (right) inhibited in same subject for same multiple dose regimen.Back to article page