Table 4 Serum concentrations for morphine and metabolites for the subcutaneous route The morphine doses (mg/24 h) vary because of variable doses of rescue morphine. A total of 17 trial periods in 10 patients were studied. All data are given as median and range.
Day 1 | Day 2 | Day 3 | Day 4 | |
|---|---|---|---|---|
Morphine dose (mg/24 h) | 135 (30–340) | 163 (30 – 335) | 164 (50 – 440) | 150 (84 – 440) |
Serum morphine (nmol/l) | 240 (42–741) | 254 (62–1297) | 305 (106–1045) | 373 (103–1222) |
Serum M6G (nmol/l) | 723 (78–1811) | 674 (88–2867) | 1009 (374–2023) | 1225 (400–2339) |
Serum M3G (nmol/l) | 5350 (578–11784) | 4490 (779–16312) | 5631 (3028–8342) | 6119 (2777–13715) |