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Table 4 Serum concentrations for morphine and metabolites for the subcutaneous route The morphine doses (mg/24 h) vary because of variable doses of rescue morphine. A total of 17 trial periods in 10 patients were studied. All data are given as median and range.

From: Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study

  Day 1 Day 2 Day 3 Day 4
Morphine dose (mg/24 h) 135 (30–340) 163 (30 – 335) 164 (50 – 440) 150 (84 – 440)
Serum morphine (nmol/l) 240 (42–741) 254 (62–1297) 305 (106–1045) 373 (103–1222)
Serum M6G (nmol/l) 723 (78–1811) 674 (88–2867) 1009 (374–2023) 1225 (400–2339)
Serum M3G (nmol/l) 5350 (578–11784) 4490 (779–16312) 5631 (3028–8342) 6119 (2777–13715)