Figure 13

Determination of arterial concentration by deconvolution of the experimental antecubital vein concentration data for thiopental. The top panel shows the experimental arterial and antecubital vein data (squares) of Barrett et. al. [9] and the model predictions using the whole body and "arm" PBPK parameters described in fig. 4 (using fr_muscle = 0.05). The middle panel compares the arterial concentration (black line) determined by deconvolution of the antecubital vein experimental data (blue squares, top panel) versus the experimental arterial data (black squares). The bottom panel compares the antecubital concentration (red line) determined by convolution of the arterial concentration (black line, middle panel) versus the experimental antecubital data (black squares).