Figure 12
Determination of arterial concentration by deconvolution of the model antecubital vein concentration data. The top panel shows the model arterial (red) and antecubital (blue) concentration determined using the toluene PBPK model and a value of frmuscle = 0.5. The bottom panel compares the arterial concentration (black line, bottom panel) determined by deconvolution of the antecubital vein discrete data (blue squares, top panel) with the true model arterial concentration (red line, bottom panel).