The pharmacokinetics of the interstitial space in humans

Table 6 Spreadsheat description of PBPK parameters for the 70 Kg, 20% fat "standardhuman".

Organ	Weight (Kg)	Lipid Fraction	Solid Fraction	Solid (Kg)	ecf Fraction	water (L)	water /Kg	ecf water(L)	flow (L/Kg)	flow (L/min)	Ka	Ka*ecf
Blood	5.5	0	0.18	0.99	0.595	4.51	0.82	2.68345
liver	1.8	0	0.3	0.54	0.23	1.26	0.7	0.2898	0.25	0.45	0.5	0.1449
portal	1.5	0	0.22	0.33	0.3	1.17	0.78	0.351	0.75	1.125	0.35	0.1228
muscle	26	0	0.22	5.72	0.15	20.28	0.78	3.042	0.0225	0.585	0.5	1.521
kidney	0.31	0	0.2	0.062	0.165	0.248	0.8	0.04092	4	1.24	0.35	0.0143
brain	1.4	0	0.2	0.28	0	1.12	0.8	0	0.56	0.784	0.1	0
heart	0.33	0	0.2	0.066	0.25	0.264	0.8	0.066	0.8	0.264	0.5	0.033
lung	0.536	0	0.2	0.107	0.2	0.428	0.8	0.08576	10.482	5.6184	0.35	0.03
skin	2.6	0	0.3	0.78	0.6	1.82	0.7	1.092	0.1	0.26	0.25	0.273
tendon	3	0	0.15	0.45	1	2.55	0.85	2.55	0.01	0.03	0.25	0.6375
other	5.524	0	0.15	0.828	0.8	4.695	0.85	3.75632	0.02	0.1104	0.25	0.9390
bone	4	0	1	4	0.5	0	0	0		0	0	0
adipose	17.5	0.8	0	0	1	3.5	0.2	3.5	0.044	0.77	0.35	1.225
Total	70	0.2		14.15		41.84		17.4572		5.6184		4.9406