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Table 6 Spreadsheat description of PBPK parameters for the 70 Kg, 20% fat "standardhuman".

From: The pharmacokinetics of the interstitial space in humans

Organ Weight (Kg) Lipid Fraction Solid Fraction Solid (Kg) ecf Fraction water (L) water /Kg ecf water(L) flow (L/Kg) flow (L/min) Ka Ka*ecf
Blood 5.5 0 0.18 0.99 0.595 4.51 0.82 2.68345     
liver 1.8 0 0.3 0.54 0.23 1.26 0.7 0.2898 0.25 0.45 0.5 0.1449
portal 1.5 0 0.22 0.33 0.3 1.17 0.78 0.351 0.75 1.125 0.35 0.1228
muscle 26 0 0.22 5.72 0.15 20.28 0.78 3.042 0.0225 0.585 0.5 1.521
kidney 0.31 0 0.2 0.062 0.165 0.248 0.8 0.04092 4 1.24 0.35 0.0143
brain 1.4 0 0.2 0.28 0 1.12 0.8 0 0.56 0.784 0.1 0
heart 0.33 0 0.2 0.066 0.25 0.264 0.8 0.066 0.8 0.264 0.5 0.033
lung 0.536 0 0.2 0.107 0.2 0.428 0.8 0.08576 10.482 5.6184 0.35 0.03
skin 2.6 0 0.3 0.78 0.6 1.82 0.7 1.092 0.1 0.26 0.25 0.273
tendon 3 0 0.15 0.45 1 2.55 0.85 2.55 0.01 0.03 0.25 0.6375
other 5.524 0 0.15 0.828 0.8 4.695 0.85 3.75632 0.02 0.1104 0.25 0.9390
bone 4 0 1 4 0.5 0 0 0   0 0 0
adipose 17.5 0.8 0 0 1 3.5 0.2 3.5 0.044 0.77 0.35 1.225
Total 70 0.2   14.15   41.84   17.4572   5.6184   4.9406