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Table 3 Steady state volume of distribution (VSS) and interstitial volume (VI) relative to body weight for β-lactam antibiotics as a function of degree of protein binding.

From: The pharmacokinetics of the interstitial space in humans

Solute

Reference

Fraction Bound

VSS (liters/Kg)

VI (liters/Kg)

amoxicillin

[62]

.17–.23

.26

.22

 

[61]

 

.267

.23

piperacillin

[30]

.48

.23

.19

cefatrizine

[31]

.62

.194

.155

ceforanide

[32]

.82

.161

.12

dicloxacilllin

[63]

.97

.091

.053

amoxicillin

[29]

.17–.23

.33

.29

flucloxacillin

 

.93

.15

.11

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BMC Clinical Pharmacology

ISSN: 1472-6904