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Table 3 Steady state volume of distribution (VSS) and interstitial volume (VI) relative to body weight for β-lactam antibiotics as a function of degree of protein binding.

From: The pharmacokinetics of the interstitial space in humans

Solute Reference Fraction Bound VSS (liters/Kg) VI (liters/Kg)
amoxicillin [62] .17–.23 .26 .22
  [61]   .267 .23
piperacillin [30] .48 .23 .19
cefatrizine [31] .62 .194 .155
ceforanide [32] .82 .161 .12
dicloxacilllin [63] .97 .091 .053
amoxicillin [29] .17–.23 .33 .29
flucloxacillin   .93 .15 .11