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Table 1 Steady-state Volume of Distribution relative to body weight (VSS) and total body water (VSSW) for selected solutes.

From: The pharmacokinetics of the interstitial space in humans

Solute

Reference

Fraction Bound

VSS (liters/Kg)

VSSW (liters/liter)

Comments

   

2-expon

3-expon

  

Mannitol

[58]

≈ 0

.28

 

.48

N = 7, 28 years, 70.9 Kg, 178 cm.

EDTA

 

≈ 0

.265

 

.45

 

Mannitol

[57]

≈ 0

.33

.33

.56

N = 1, 71.6 Kg, 172 cm.

amoxicillin

[62]

.17 – .23

.262

.275

.44

N = 9, 66.4 Kg

 

[61]

 

.267

.253

.45

N = 9, 74.7 Kg, 180 cm

morphine-6-glucuronide

[59]

0–.1

.247

.245

.42

N = 20, 74.2 Kg

 

[42]

 

.30

.40

.50

N = 10, 71 Kg

morphine-3-glucuronide

[60]

 

.275

.273

.47

N = 3, Dose/Kg

inulin

[37]

≈ 0

.133

.131

.22

N = 1, 87.3 Kg, 173 cm

 

[39]

≈ 0

.131

.136

.23

N = 1 77.1 Kg 186 cm

 

[40]

≈ 0

.20

.277

.34

N = 27 Non-linear.

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BMC Clinical Pharmacology

ISSN: 1472-6904