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Table 1 Steady-state Volume of Distribution relative to body weight (VSS) and total body water (VSSW) for selected solutes.

From: The pharmacokinetics of the interstitial space in humans

Solute Reference Fraction Bound VSS (liters/Kg) VSSW (liters/liter) Comments
    2-expon 3-expon   
Mannitol [58] ≈ 0 .28   .48 N = 7, 28 years, 70.9 Kg, 178 cm.
EDTA   ≈ 0 .265   .45  
Mannitol [57] ≈ 0 .33 .33 .56 N = 1, 71.6 Kg, 172 cm.
amoxicillin [62] .17 – .23 .262 .275 .44 N = 9, 66.4 Kg
  [61]   .267 .253 .45 N = 9, 74.7 Kg, 180 cm
morphine-6-glucuronide [59] 0–.1 .247 .245 .42 N = 20, 74.2 Kg
  [42]   .30 .40 .50 N = 10, 71 Kg
morphine-3-glucuronide [60]   .275 .273 .47 N = 3, Dose/Kg
inulin [37] ≈ 0 .133 .131 .22 N = 1, 87.3 Kg, 173 cm
  [39] ≈ 0 .131 .136 .23 N = 1 77.1 Kg 186 cm
  [40] ≈ 0 .20 .277 .34 N = 27 Non-linear.