Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 6 | BMC Clinical Pharmacology

Figure 6

From: The pharmacokinetics of the interstitial space in humans

Figure 6

Comparison of PBPK linear (left) or semi-log (right) plots of model predictions and experimental data for inulin. The parameters rclr, mecf, and fclear [muscle] were adjusted to give the optimal fit to the data of Odeh et. al. [37] (top row). These values of mecf and fclear [muscle] were then used to fit the experimental data of Orlando et. al. [38] (second row), Ladegaard-Pedersen et. al. [39] (third row) and Prescott et. al. [40] (bottom row), varying only the renal clearance to obtain the best fit.

Back to article page