Comparison of PBPK linear (left) or semi-log (right) plots of model predictions and experimental data for inulin. The parameters rclr, mecf, and fclear [muscle] were adjusted to give the optimal fit to the data of Odeh et. al.  (top row). These values of mecf and fclear [muscle] were then used to fit the experimental data of Orlando et. al.  (second row), Ladegaard-Pedersen et. al.  (third row) and Prescott et. al.  (bottom row), varying only the renal clearance to obtain the best fit.