Figure 1

Arterial (black) and antecubital vein (red) concentrations of ⁹⁹Tc^m-DTPA (right column) and inulin (left column) after a bolus injection using the experimental data (squares) of Cousins et. al. [56]. The solid lines indicate the PBPK model predictions for the arterial (black) and antecubital vein (red) concentrations. The top row shows a plot of the absolute concentration and the bottom row is a semi-log plot of the same data. The PBPK parameters for DTPA were identical to those used for EDTA (see fig. 3).