Figure 15

Evaluation of deconvolution methods for two component intestinal input with exact data. The green line is the composite intestinal input to the PBPK model consisting of the same gamma input used in figs. 9 to 14, plus a second, smaller, delayed gamma input. The black line is the intestinal input determined by application of the four deconvolution methods to the exact venous concentration data. The "spline" and "uniform" deconvolution methods use the "default" input parameters and the "analytical" method uses a smoothing parameter of 0.