Skip to main content
Figure 3 | BMC Clinical Pharmacology

Figure 3

From: PKQuest: capillary permeability limitation and plasma protein binding – application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics

Figure 3

Comparison of the capillary permeability limited model prediction (solid line) and the experimental data (squares) for ceftriaxone venous plasma concentrations. The four panels correspond to inputs of 0.15, 0.5, 1.5 and 3.0 grams given as a 5 minute constant IV infusion. Because the protein binding saturates, the effective capillary permeability limitation (fclear) decreases as the concentration increases.

Back to article page

BMC Clinical Pharmacology

ISSN: 1472-6904