Table 2 Area under the serum concentration time curve (AUC0-∞) of codeine and its metabolites (n = 12).
From: Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers
[pmol ml-1*h] | codeine + placebo mean (95% CI) | codeine + diclofenac mean (95% CI) | p level |
|---|---|---|---|
AUC codeine | 2416 (2025–2807) | 2515 (2176–2855) | n.s. |
AUC C-6-G | 29550 (26190–32910) | 31120 (28150–34090) | < 0.05 |
AUC norcodeine | 342 (257–428) | 338 (228–448) | n.s. |
AUC morphine | 94.5 (52.9–136) | 92.1 (53.8–131) | n.s. |
AUC M-3-G | 2137 (1298–2976) | 2259 (1427–3091) | n.s. |
AUC M-6-G | 425 (254–596) | 471 (298–644) | < 0.05 |
AUC normorphine | 540 (396–684) | 549 (387–710) | n.s. |