Table 3 Incidence Rates of ADR by Regimen per 100 person-years of Treatment
From: Adverse drug reactions to antiretroviral therapy (ARVs): incidence, type and risk factors in Nigeria
Specific ADR by Organ System | AZT_based (n) | d4T_based (n) | TDF_based (n) | Total (%) |
|---|---|---|---|---|
Gastrointestinal | Â | Â | Â | Â |
Abdominal pain | - | 0.09 (1) | - | 1 (1.20) |
Diarrhea | 0.32 (4) | - | - | 4 (4.82) |
Dyspepsia | 0.08 (1) | - | - | 1 (1.20) |
Nausea & Vomiting | 0.24 (3) | - | - | 3 (3.61) |
Cardiovascular/Respiratory System | Â | Â | Â | Â |
Chest pain | - | 0.09 (1) | - | 1 (1.20) |
Cough | - | 0.09 (1) | - | 1 (1.20) |
Skin and Appendages | Â | Â | Â | Â |
Pruritus | 0.24 (3) | 0.61 (7) | - | 10 (12.05) |
Steven Johnson syndrome | 0.08 (1) | - | - | 1 (1.20) |
Skin rash | 0.64 (8) | 0.52 (6) | 2.56 (1) | 15 (18.07) |
Central and Peripheral Nervous System | Â | Â | Â | Â |
Headache | 0.08 (1) | 0.09 (1) | - | 2 (2.41) |
Dizziness | 0.08 (1) | 0.44 (5) | - | 6 (7.23) |
Insomnia | 0.16 (2) | - | - | 2 (2.41) |
Nightmare | 0.08 (1) | 0.09 (1) | - | 2 (2.41) |
Pain/Tingling/Numbness | 0.08 (1) | 2.09 (24) | - | 25 (30.12) |
Musculoskeletal System | Â | Â | Â | Â |
Myalgia | 0.08 (1) | - | - | 1 (1.20) |
Systemic Signs/Symptoms | Â | Â | Â | Â |
Rigor | 0.08 (1) | - | - | 1 (1.20) |
Fatigue | 0.08 (1) | - | - | 1 (1.20) |
Fever | 0.08 (1) | - | - | 1 (1.20) |
Total | 34 | 48 | 1 | 83 |