A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka

Table 2 Incremental cost per life saved for baseline data and following one way sensitivity analysis (Number of lives saved as the final outcome measure)

	Incremental cost per life saved(LKR/Life saved)
	0-10 hrs	10-24 hrs
Baseline results	Not applicable^‡	316,182
One way sensitivity analysis results
*Increasing by 50%*
NAC deaths	Not applicable^‡	469,173
NAC cost	Not applicable^‡	565,805
Methionine deaths	Not applicable^‡	173,147
Methionine cost	Not applicable^‡	265,107
*Decreasing by 50%*
NAC deaths	Not applicable^‡	238,432
NAC cost	Not applicable^‡	55,312
Methionine deaths	Not applicable^‡	1,818,046
Methionine cost	Not applicable^‡	366,486
*Upper confidence interval(CI)*
NAC deaths	Dominance for methionine ^†	909,023
NAC hepatotoxicity	Not applicable^‡	445,229
Methionine deaths	5,365,130	73,456
Methionine hepatotoxicity	Not applicable^‡	94,349
*Lower confidence interval(CI)*
NAC deaths	Not applicable^‡	229,648
NAC hepatotoxicity	Not applicable^‡	268,907
Methionine deaths	Not applicable^‡	Dominance for methionine ^†
Methionine hepatotoxicity	Not applicable	836,480

^‡ The outcome resulted from alternative interventions were similar therefore cost effectiveness ratios were not calculated.
^† Methionine shows strong dominance for a decision as the incremental effectiveness was lower while the incremental cost is higher for NAC (methionine saves more lives at a lower cost)