BMC Clinical Pharmacology

Table 3 Comparison of Slopes for 0 to 10 Hour AUC vs Thiamine Dose

From: Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects

	AUC_{0-10 hr}		C_max
Segment	Slope	p -value*	Slope	p -value*
0 to 100 mg
whole blood	2.14		0.40
plasma	1.76		0.39
100 mg to 500 mg
whole blood	1.02	< 0.01	0.14	< 0.01
plasma	1.09	0.06	0.18	< 0.01
500 mg to 1500 mg
whole blood	1.42	0.06	0.29	0.03
plasma	1.45	0.40	0.29	0.08

*Compared to the 0 to 100 mg segment

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