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Table 3 Comparison of Slopes for 0 to 10 Hour AUC vs Thiamine Dose

From: Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects

  AUC0-10 hr Cmax
Segment Slope p -value* Slope p -value*
0 to 100 mg     
   whole blood 2.14   0.40  
   plasma 1.76   0.39  
100 mg to 500 mg     
   whole blood 1.02 < 0.01 0.14 < 0.01
   plasma 1.09 0.06 0.18 < 0.01
500 mg to 1500 mg     
   whole blood 1.42 0.06 0.29 0.03
   plasma 1.45 0.40 0.29 0.08
  1. *Compared to the 0 to 100 mg segment