Table 3 Results of the multiple logistic regression models concerning the association between TZD exposure and 4 ADRs: Heart Failure, Myocardial Infarction, Edema and Hepatitis.
Heart failure | Odds ratio | (95% CI) | P |
|---|---|---|---|
Age | 1.04 | (0.99 - 1.09) | 0.0705 |
Obesity | 5.69 | (1.34 - 24.20) | 0.0185 |
Thiazolidinediones | 65.39 | (17.678 - 241.93) | <0.0001 |
Hosmer and Lemeshow procedure | 0.32 | ||
Myocardial infarction | |||
Age | 0.97 | (0.95 - 1.00) | 0.1076 |
Gender | 1.73 | (0.78 - 3.84) | 0.1727 |
Thiazolidinediones | 0.42 | (0.05 - 3.17) | 0.4039 |
Heart valve disorders | 25.95 | (2.63 - 255.47) | 0.0053 |
Hypertension | 0.34 | (0.09 - 1.19) | 0.0929 |
Hosmer and Lemeshow procedure | 0.8254 | ||
Edema | |||
Obesity | 1.89 | (0.58 - 6.17) | 0.2863 |
Thiazolidinediones | 25.09 | (13.50 - 46.63) | <0.0001 |
Biguanides | 0.42 | (0.20 - 0.87) | 0.02 |
Hosmer and Lemeshow procedure | 0.8043 | ||
Hepatitis | |||
Age | 0.99 | (0.97 - 1.00) | 0.1167 |
Angina pectoris | 0.43 | (0.13 - 1.39) | 0.1620 |
Cardiac arrhythmia | 0.36 | (0.08 - 1.52) | 0.1686 |
Cardiac insufficiency | 0.58 | (0.25 - 1.37) | 0.2217 |
Thiazolidinediones | 0.84 | (0.40 - 1.78) | 0.6645 |
Non Steroidal Anti-Inflammatory Drugs | 1.85 | (1.13 - 3.01) | 0.0134 |
Diuretics | 0.58 | (0.32 - 1.06) | 0.0796 |
Calcium inhibitors | 0.63 | (0.32 -1.23) | 0.1798 |
Angiotensin II inhibitors | 0.68 | (0.35 - 1.32) | 0.2804 |
Hosmer and Lemeshow procedure | 0.4397 | ||