
Degree of hepatic impairment*

Degree of renal impairment^{†}


PK parameter

Mild

Moderate

Severe

Mild

Moderate

Severe


C_{max} ratio (90% CI)

0.93 (0.751.15)

0.89 (0.721.10)

0.95 (0.771.17)

1.07 (0.971.19)

1.09 (0.961.24)

1.12 (0.961.30)

AUC ratio (90% CI)

1.40 (0.912.17)

1.45 (0.942.24)

2.90 (1.884.49)

1.66 (1.381.99)

1.89 (1.502.39)

2.17 (1.642.86)

t_{1/2} difference, h (90% CI)







1.87 (0.063.68)**

2.37 (0.084.66)**

2.87 (0.15.64)**

 *Point estimate of geometric mean ratio in relation to control; ^{†}Point estimate of geometric least squares ratio in relation to control; **Least squares mean difference in relation to control; AUC, area under the plasma concentrationtime curve from zero to infinity; C_{max}, maximum plasma concentration; t_{1/2}, terminal halflife; CI = confidence interval.