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Table 1 Pharmacokinetic parameters for free phenoxodiol following a single bolus dose of 5 mg/kg infused intravenously over 5 minutes.

From: Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer

Patient

Kel

T1/2 (h)

AUC0-t (μg.h/ml)

AUC0-inf (μg.h/ml)

Cl (L/h)

Vd (L/kg)

1

1.25

0.55

1.49

1.55 (4.1%)*

1.50

1.20

2

2.42

0.28

0.40

0.40 (1.2%)

7.01

2.90

3

1.59

0.43

1.04

1.05 (13.2%)

2.22

1.40

4

1.24

0.56

1.65

1.66 (10.3)

1.24

1.00

5

0.39

1.74

2.59

2.59 (11.3)

0.46

1.17

6

1.54

0.45

1.21

1.22 (11.8%)

2.46

1.60

Mean ± SD

1.41 ± 0.66

0.67 ± 0.53

1.40 ± 0.73

1.41 ± 0.73 (8.7%)

2.48 ± 2.33

1.55 ± 0.69

  1. Kel is the elimination rate constant. T1/2 is the terminal half life. AUC0-t is the area under the plasma concentration versus time curve measured to the last plasma sample. AUC0-inf is the area under the plasma concentration versus time curve extrapolated to infinity. Cl is the plasma clearance rate. Vd is the apparent volume of distribution. *The figures in parentheses are the estimated free phenoxodiol proportion for each patient, based on the calculation free AUC0-inf x100/total AUC0-inf
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BMC Clinical Pharmacology

ISSN: 1472-6904