EVITA: a tool for the early EValuation of pharmaceutical Innovations with regard to Therapeutic Advantage

Table 3 Efficiency Profil e

RCTs showing evidence of	number of RCT	patient relevant outcome	surrogate outcome
	0	0	0
superiority	1	+5.0	+2.5
	≥2	+7.5	+3.75
	0	0	0
non-inferiority/equivalence (in the presence of other RCT showing superiority)	1	-1.67	-0.83
	≥2	-2.5	-1.25
non-inferiority/equivalence (in the absence of other RCT)	any	0	0
	0	0	0
non-inferiority/equivalence (in the presence of other RCT showing inferiority)	1	+1.67	+0.83
	≥2	+2.5	+1.25
	0	0	0
inferiority	1	-5.0	-2.5
	≥2	-7.5	-3.75
sum		...
modifier		...
efficiency score		...

Efficiency score according to number of RCTs and outcome variables investigated as well as modification by strength of effect as extracted by the modifier assessment (Table 2).