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  1. Voriconazole was introduced for the treatment of life-threatening fungal infections. The intravenous form includes the solvent vehicle sulphobutylether beta cyclodextrin sodium which shows an impaired clearanc...

    Authors: Marc A von Mach, Jürgen Burhenne and Ludwig S Weilemann

    Citation: BMC Clinical Pharmacology 2006 6:6

    Content type: Research article

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  2. Since plant extracts are increasingly used as phytotherapeutics or dietary supplements information on bioavailability, bioefficacy and safety are warranted. We elucidated the plasma kinetics of genuine extract...

    Authors: Tanja Grimm, Roswitha Skrabala, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdeňka Ďuračková and Petra Högger

    Citation: BMC Clinical Pharmacology 2006 6:4

    Content type: Research article

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  3. Although rare, serum sickness-like reactions have been documented to occur following the administration of many antibiotics. Cefazolin, a first generation cephalosporin, is a commonly prescribed antibiotic whi...

    Authors: Michael Brucculeri, Marian Charlton and David Serur

    Citation: BMC Clinical Pharmacology 2006 6:3

    Content type: Case report

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  4. The taxanes paclitaxel and docetaxel have traditionally been used in high doses every third week in the treatment of cancer. Lately there has been a trend towards giving weekly low doses to improve the therape...

    Authors: Anders Andersen, David J Warren, Paal F Brunsvig, Steinar Aamdal, Gunnar B Kristensen and Harald Olsen

    Citation: BMC Clinical Pharmacology 2006 6:2

    Content type: Technical advance

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  5. Streptokinase (SK) is an effective fibrinolytic agent for the treatment of acute myocardial infarction (AMI). The objective of the present study was to assess the adverse drug reactions (ADRs) associated with ...

    Authors: Blas Y Betancourt, María A Marrero-Miragaya, Giset Jiménez-López, Carmen Valenzuela-Silva, Elizeth García-Iglesias, Francisco Hernández-Bernal, Francisco Debesa-García, Tania González-López, Leovaldo Alvarez-Falcón and Pedro A López-Saura

    Citation: BMC Clinical Pharmacology 2005 5:5

    Content type: Research article

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  6. Isoflavones from soybeans may provide some beneficial impacts on postmenopausal health. The purpose of this study was to compare the pharmacokinetics and bioavailability of plasma isoflavones (daidzein and gen...

    Authors: Ekasin Anupongsanugool, Supanimit Teekachunhatean, Noppamas Rojanasthien, Saipin Pongsatha and Chaichan Sangdee

    Citation: BMC Clinical Pharmacology 2005 5:2

    Content type: Research article

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  7. Sales data indicate a major increase in the prescription of antifungal drugs in the last two decades. Many new agents for systemic use that only recently have become available are likely to be prescribed inten...

    Authors: Katja de With, Michaela Steib-Bauert, Holger Knoth, Frank Dörje, Egid Strehl, Ulrich Rothe, Ludwig Maier and Winfried V Kern

    Citation: BMC Clinical Pharmacology 2005 5:1

    Content type: Research article

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  8. The feasibility of drug monitoring of serum concentrations of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) during chronic morphine therapy is not established. One important factor re...

    Authors: Pål Klepstad, Priscilla Hilton, Jorunn Moen, Stein Kaasa, Petter C Borchgrevink, Kolbjørn Zahlsen and Ola Dale

    Citation: BMC Clinical Pharmacology 2004 4:7

    Content type: Research article

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  9. Oxidative and nitrosative stress have been involved in gentamicin-induced nephrotoxicity. The purpose of this work was to study the effect of S-allylmercaptocysteine, a garlic derived compound, on gentamicin-i...

    Authors: José Pedraza-Chaverrí, Diana Barrera, Perla D Maldonado, Yolanda I Chirino, Norma A Macías-Ruvalcaba, Omar N Medina-Campos, Leticia Castro, Marcos I Salcedo and Rogelio Hernández-Pando

    Citation: BMC Clinical Pharmacology 2004 4:5

    Content type: Research article

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  10. Albumin is the most abundant protein in blood plasma, and due to its ligand binding properties, serves as a circulating depot for endogenous and exogenous (e.g. drugs) compounds. Hence, the unbound drug is the...

    Authors: Harald Olsen, Anders Andersen, Arve Nordbø, Ulf E Kongsgaard and Ole P Børmer

    Citation: BMC Clinical Pharmacology 2004 4:4

    Content type: Research article

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  11. The present study aimed at investigating in healthy volunteers the effects of diazepam and clonazepam on beta-cell function, insulin sensitivity and glucose effectiveness based on the frequently sampled intrav...

    Authors: Hugues Chevassus, Isabelle Mourand, Nathalie Molinier, Bruno Lacarelle, Jean-Frédéric Brun and Pierre Petit

    Citation: BMC Clinical Pharmacology 2004 4:3

    Content type: Research article

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  12. Chronic atrial fibrillation is a prevalent cardiac disorder. The literature indicates varying proportions of those treated with anticoagulants, and varying intensity of anticoagulation. Electronic patient reco...

    Authors: Gunnar H Nilsson and Ingela Björholt

    Citation: BMC Clinical Pharmacology 2004 4:1

    Content type: Research article

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  13. Niacin is widely available over the counter (OTC). We sought to determine the safety of 500 mg immediate release niacin, when healthy individuals use them as directed.

    Authors: Edward Mills, Jonathan Prousky, Gannady Raskin, Joel Gagnier, Beth Rachlis, Victor M Montori and David Juurlink

    Citation: BMC Clinical Pharmacology 2003 3:4

    Content type: Research article

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  14. The pharmacokinetics of extracellular solutes is determined by the blood-tissue exchange kinetics and the volume of distribution in the interstitial space in the different organs. This information can be used ...

    Authors: David G Levitt

    Citation: BMC Clinical Pharmacology 2003 3:3

    Content type: Research article

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  15. Desferrioxamine (DFO) is an important iron chelating agent. It has also been thought of as an agent with anti-oxidant potential as it chelates ferric iron in various parts of the body. However, there is eviden...

    Authors: Yutaka Niihara, Junli Ge, Oded Shalev, Huiyuan Wu, Amy Tu and Kouichi R Tanaka

    Citation: BMC Clinical Pharmacology 2002 2:8

    Content type: Research article

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  16. It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This assumption may not be valid if there is a large amount ...

    Authors: David G Levitt

    Citation: BMC Clinical Pharmacology 2002 2:7

    Content type: Research article

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  17. Management of thalassemia major requires patients to have life-long access to a treatment regimen of regular blood transfusions coupled with iron chelation therapy. The objective of this study was to investiga...

    Authors: Alexandra Ward, J Jaime Caro, Traci Craig Green, Krista Huybrechts, Alejandro Arana, Suzanne Wait and Androulla Eleftheriou

    Citation: BMC Clinical Pharmacology 2002 2:3

    Content type: Research article

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  18. Previously, we have demonstrated a marked inhibition of codeine glucuronidation by diclofenac in human liver tissue homogenate. We therefore aimed to investigate whether diclofenac inhibits glucuronidation of ...

    Authors: Susanne Ammon, Claudia Marx, Christoph Behrens, Ute Hofmann, Thomas Mürdter, Ernst-Ulrich Griese and Gerd Mikus

    Citation: BMC Clinical Pharmacology 2002 2:2

    Content type: Research article

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  19. It is commonly agreed that people with a high blood LDL-cholesterol will have a higher risk of coronary artery disease (CAD) than people with low blood LDL-cholesterol. Due to the increasingly high costs of me...

    Authors: Viroj Wiwanitkit MD, Danai Wangsaturaka MD and Oranee Tangphao MD

    Citation: BMC Clinical Pharmacology 2002 2:1

    Content type: Research article

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  20. Routine antibiotic prophylaxis following snakebite is not recommended but evidence suggests that it may be common practice in Zimbabwe. This study set out to determine and describe the extent of this practice ...

    Authors: Dexter D Tagwireyi, Douglas E Ball and Charles FB Nhachi

    Citation: BMC Clinical Pharmacology 2001 1:4

    Content type: Research article

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  21. This paper assess the relationship between the quantity of three anti-seizure medications in hair and the color of the analyzed hair, while controlling for the effects of dose, dose duration, and patient age f...

    Authors: Tom Mieczkowski, Aristidis M Tsatsakis, Michael Kruger and Thanasis Psillakis

    Citation: BMC Clinical Pharmacology 2001 1:2

    Content type: Research article

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  22. The use of low-dose aspirin has been reported to be associated with an increased risk of upper gastrointestinal complications (UGIC). The coating of aspirin has been proposed as an approach to reduce such a ri...

    Authors: Francisco J de Abajo and Luis A García Rodríguez

    Citation: BMC Clinical Pharmacology 2001 1:1

    Content type: Case control study

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