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  1. The antimicrobial resistance is a global problem, probably due to the indiscriminate and irrational use of antibiotics, prescriptions for incorrect medicines or incorrect determinations of dose, route and/or d...

    Authors: Edelberto Silva, Jorge A Díaz, María J Arias, Angela P Hernández and Andrés de la Torre

    Citation: BMC Clinical Pharmacology 2010 10:3

    Content type: Research article

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  2. Several randomised clinical trials (RCTs) of analgesics in postoperative pain after traumatic or orthopaedic surgery (TOS) have been published, but no studies have assessed the quality of these reports. We aim...

    Authors: Eva Montané, Antoni Vallano, Xavier Vidal, Cristina Aguilera and Joan-Ramon Laporte

    Citation: BMC Clinical Pharmacology 2010 10:2

    Content type: Research article

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  3. The goal of physiologically based pharmacokinetics (PBPK) is to predict drug kinetics from an understanding of the organ/blood exchange. The standard approach is to assume that the organ is "flow limited" whic...

    Authors: David G Levitt

    Citation: BMC Clinical Pharmacology 2010 10:1

    Content type: Research article

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  4. The aim of this study was to compare the pharmacokinetic properties of sodium ibuprofen and ibuprofen acid incorporating poloxamer with standard ibuprofen acid tablets.

    Authors: Peter M Dewland, Sandie Reader and Phillip Berry

    Citation: BMC Clinical Pharmacology 2009 9:19

    Content type: Research article

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  5. Serum paraoxonase (PON1) is a high density lipoprotein (HDL)-associated enzyme involved in organophosphate (OP) degradation and prevention of atherosclerosis. PON1 comprises a potential candidate for in vivo ther...

    Authors: Leonid Gaidukov, Dganit Bar, Shiri Yacobson, Esmira Naftali, Olga Kaufman, Rinat Tabakman, Dan S Tawfik and Etgar Levy-Nissenbaum

    Citation: BMC Clinical Pharmacology 2009 9:18

    Content type: Research article

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  6. This study investigated the effects of oral dimercapto succinic acid (DMSA) therapy on the behavioural symptoms of children with autism spectrum disorders (ASD) ages 3-8 years.

    Authors: James B Adams, Matthew Baral, Elizabeth Geis, Jessica Mitchell, Julie Ingram, Andrea Hensley, Irene Zappia, Sanford Newmark, Eva Gehn, Robert A Rubin, Ken Mitchell, Jeff Bradstreet and Jane El-Dahr

    Citation: BMC Clinical Pharmacology 2009 9:17

    Content type: Research article

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  7. This study investigated the effect of oral dimercapto succinic acid (DMSA) therapy for children with autism spectrum disorders ages 3-8 years.

    Authors: James B Adams, Matthew Baral, Elizabeth Geis, Jessica Mitchell, Julie Ingram, Andrea Hensley, Irene Zappia, Sanford Newmark, Eva Gehn, Robert A Rubin, Ken Mitchell, Jeff Bradstreet and Jane El-Dahr

    Citation: BMC Clinical Pharmacology 2009 9:16

    Content type: Research article

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  8. The objectives of this pilot study were to evaluate treatment quality for the risk factors of hypertension, diabetes and hyperlipidemia as well as the overall treatment quality for patients on an internal neph...

    Authors: Gunar Stemer, Sonja Zehetmayer and Rosa Lemmens-Gruber

    Citation: BMC Clinical Pharmacology 2009 9:15

    Content type: Research article

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  9. The selective MAO-B inhibitor selegiline has been evaluated in clinical trials as a potential medication for the treatment of cocaine dependence. This study evaluated the safety of and pharmacologic interactio...

    Authors: Debra S Harris, Thomas Everhart, Peyton Jacob III, Emil Lin, John E Mendelson and Reese T Jones

    Citation: BMC Clinical Pharmacology 2009 9:13

    Content type: Research article

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  10. Multiple medications is a well-known potential risk factor in terms of patient's health. The aim of the present study was to estimate the prevalence of dispensed drugs and multiple medications in an entire nat...

    Authors: Bo Hovstadius, Bengt Åstrand and Göran Petersson

    Citation: BMC Clinical Pharmacology 2009 9:11

    Content type: Technical advance

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  11. HX575 is a human recombinant epoetin alfa that was approved for use in Europe in 2007 under the European Medicines Agency biosimilar approval pathway. Therefore, in order to demonstrate the bioequivalence of H...

    Authors: Fritz Sörgel, Ursula Thyroff-Friesinger, Andrea Vetter, Bernhard Vens-Cappell and Martina Kinzig

    Citation: BMC Clinical Pharmacology 2009 9:10

    Content type: Research article

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  12. The frequency of drug prescription errors is high. Excluding errors in decision making, the remaining are mainly due to order ambiguity, non standard nomenclature and writing illegibility. The aim of this stud...

    Authors: Laura Calligaris, Angela Panzera, Luca Arnoldo, Carla Londero, Rosanna Quattrin, Maria G Troncon and Silvio Brusaferro

    Citation: BMC Clinical Pharmacology 2009 9:9

    Content type: Research article

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  13. Adverse Drug Reactions (ADRs) have been regarded as a major public health problem since they represent a sizable percentage of admissions. Unfortunately, there is a wide variation of ADR related admissions amo...

    Authors: Miran Brvar, Nina Fokter, Matjaz Bunc and Martin Mozina

    Citation: BMC Clinical Pharmacology 2009 9:8

    Content type: Research article

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  14. Pharmaceutical drug poisonings have previously been reported using single sources of information, either hospital data or forensic data, which might not reveal the true incidence. We therefore aimed to estimat...

    Authors: Anna K Jönsson, Olav Spigset, Micaela Tjäderborn, Henrik Druid and Staffan Hägg

    Citation: BMC Clinical Pharmacology 2009 9:7

    Content type: Research article

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  15. Despite surveillance efforts, unexpected and serious adverse drug reactions (ADRs) repeatedly occur after marketing. The aim of this article is to analyse ADRs reported by available ADR signal detection approa...

    Authors: Lise Aagaard and Ebba Holme Hansen

    Citation: BMC Clinical Pharmacology 2009 9:4

    Content type: Research article

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  16. Propanil is an important cause of death from acute pesticide poisoning, of which methaemoglobinaemia is an important manifestation. However, there is limited information about the clinical toxicity and kinetic...

    Authors: Darren M Roberts, Renate Heilmair, Nick A Buckley, Andrew H Dawson, Mohamed Fahim, Michael Eddleston and Peter Eyer

    Citation: BMC Clinical Pharmacology 2009 9:3

    Content type: Research article

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  17. AVI-014 is an egg white-derived, recombinant, human granulocyte colony-stimulating factor (G-CSF). This healthy volunteer study is the first human investigation of AVI-014.

    Authors: Roslyn Varki, Ed Pequignot, Mark C Leavitt, Andres Ferber and Walter K Kraft

    Citation: BMC Clinical Pharmacology 2009 9:2

    Content type: Research article

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  18. Demonstration of equivalent amounts of the same active pharmaceutical ingredient (API) between generic and innovator products (pharmaceutical equivalence) is a basic requirement of regulatory agencies for intr...

    Authors: Andres F Zuluaga, Maria Agudelo, Carlos A Rodriguez and Omar Vesga

    Citation: BMC Clinical Pharmacology 2009 9:1

    Content type: Research article

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  19. Bone resorption displays marked diurnal variation. Reversible inhibition of bone resorption may result in best possible efficacy when bone resorption peaks. The aim of the study was to assess the pharmacokinet...

    Authors: MA Karsdal, I Byrjalsen, BJ Riis and C Christiansen

    Citation: BMC Clinical Pharmacology 2008 8:12

    Content type: Research article

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  20. Dexketoprofen, an NSAID used in the management of acute and chronic pains, is licensed in several countries but has not previously been the subjected of a systematic review. We used published and unpublished i...

    Authors: R Andrew Moore and Jodie Barden

    Citation: BMC Clinical Pharmacology 2008 8:11

    Content type: Research article

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  21. Prior studies suggested low density lipoprotein particle (LDLP) size is a predictor of atherosclerosis. Knowledge of effects of lipid lowering drugs on lipoprotein subclasses is useful. We treated subjects wit...

    Authors: Sammy Y Chan, GB John Mancini, Andrew Ignaszewski and Jiri Frohlich

    Citation: BMC Clinical Pharmacology 2008 8:10

    Content type: Research article

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  22. Prescribing errors are common in hospital settings. Regular review of medication charts is recommended as a way to reduce errors but it is not clear how often this happens. The aim of this study was to determi...

    Authors: Khang Li Looi and Peter N Black

    Citation: BMC Clinical Pharmacology 2008 8:9

    Content type: Research article

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  23. In the region of Västra Götaland in Sweden, prescribing guidelines, drawn up by 24 expert groups and determined by the regional board for drugs, are since 2006 available in the form of an annually published bo...

    Authors: Magnus AB Axelsson, Malin Spetz, Anders Mellén and Susanna M Wallerstedt

    Citation: BMC Clinical Pharmacology 2008 8:8

    Content type: Research article

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  24. There is a scarcity of studies addressing the factors associated with impaired fasting glucose in Chinese patients with uncomplicated hypertension. We included 1,218 patients newly prescribed a single antihype...

    Authors: Martin CS Wong, Johnny Y Jiang, H Fung, Sian Griffiths and Stewart Mercer

    Citation: BMC Clinical Pharmacology 2008 8:6

    Content type: Research article

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  25. To investigate the influence of water intake and dose timing on the pharmacokinetic and pharmacodynamic parameters of an oral formulation of salmon calcitonin (sCT).

    Authors: Morten A Karsdal, Inger Byrjalsen, Bente J Riis and Claus Christiansen

    Citation: BMC Clinical Pharmacology 2008 8:5

    Content type: Research article

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  26. We studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant.

    Authors: John E Mendelson, Dana McGlothlin, Debra S Harris, Elyse Foster, Tom Everhart, Peyton Jacob III and Reese T Jones

    Citation: BMC Clinical Pharmacology 2008 8:4

    Content type: Research article

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  27. Conscious sedation is used in dentistry to improve access and quality of care in patients who have difficulty coping with treatment. The aim of this prospective study was to describe a postgraduate training co...

    Authors: Valérie Collado, Emmanuel Nicolas, Denise Faulks, Corinne Tardieu, Marie-Cécile Manière, Dominique Droz, Peter Onody and Martine Hennequin

    Citation: BMC Clinical Pharmacology 2008 8:3

    Content type: Research article

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  28. Cases of impaired renal function have been reported in patients who had been treated with both zoledronic acid and thalidomide for myeloma. Hence, we conducted a safety study of zoledronic acid and thalidomide...

    Authors: Andrew Spencer, Andrew Roberts, Nola Kennedy, Christina Ravera, Serge Cremers, Sanela Bilic, Terry Neeman, Michael Copeman, Horst Schran and Kevin Lynch

    Citation: BMC Clinical Pharmacology 2008 8:9000

    Content type: Research article

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  29. Due to few paediatric drug safety studies, knowledge on risks of drug treatment in children is limited. The knowledge needs to be increased to make proper risk-benefit analyses possible when treating paediatri...

    Authors: Gertrud Brunlöf, Carina Tukukino and Susanna M Wallerstedt

    Citation: BMC Clinical Pharmacology 2008 8:1

    Content type: Research article

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  30. A previous study has shown that variations in threshold and intensity (lipid goal attainment) of statins for primary prevention contribute to regional differences in overall consumption of statins in Norway. O...

    Authors: Ingeborg Hartz, Solveig Sakshaug, Kari Furu, Anders Engeland, Anne Elise Eggen, Inger Njølstad and Svetlana Skurtveit

    Citation: BMC Clinical Pharmacology 2007 7:14

    Content type: Research article

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  31. The high rate of mortality due to malaria and the worldwide distribution of parasite resistance to the commonly used antimalarial drugs chloroquine and pyrimethamine emphasize the urgent need for the developme...

    Authors: Jennifer M Reynolds, Kamal El Bissati, Jens Brandenburg, Arthur Günzl and Choukri Ben Mamoun

    Citation: BMC Clinical Pharmacology 2007 7:13

    Content type: Research article

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  32. To provide doctors with producer-independent information to facilitate choice of treatment is an important task. The objective of the present study was to evaluate if an e-mail with a drug information attachme...

    Authors: Christina Edward, Anders Himmelmann and Susanna M Wallerstedt

    Citation: BMC Clinical Pharmacology 2007 7:12

    Content type: Research article

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  33. The use of nicotine replacement therapy (NRT) can almost double the chances of success for smokers to quit. Nevertheless, there is still a considerable number of cessation attempts that are made without any tr...

    Authors: Bertrand Dautzenberg, Mitchell Nides, Jean-Luc Kienzler and Anne Callens

    Citation: BMC Clinical Pharmacology 2007 7:11

    Content type: Research article

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  34. Growth hormone (GH) is used to treat growth hormone deficiency (GHD, adult and paediatric), short bowel syndrome in patients on a specialized diet, HIV-associated wasting and, in children, growth failure due t...

    Authors: Chris Brearley, Anthony Priestley, James Leighton-Scott and Michel Christen

    Citation: BMC Clinical Pharmacology 2007 7:10

    Content type: Research article

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  35. Adverse drug reactions (ADRs) are a frequent cause of mortality and morbidity to patients worldwide, with great associated costs to the healthcare providers including the NHS in England. We examined trends in ...

    Authors: Hitesh Patel, Derek Bell, Mariam Molokhia, Janakan Srishanmuganathan, Mitesh Patel, Josip Car and Azeem Majeed

    Citation: BMC Clinical Pharmacology 2007 7:9

    Content type: Research article

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  36. Adverse drug reactions (ADRs) are now recognized as an important cause of hospital admissions, with a proportion ranging from 0.9–7.9%. They also constitute a significant economic burden. We thus aimed at dete...

    Authors: KJ Patel, MS Kedia, D Bajpai, SS Mehta, NA Kshirsagar and NJ Gogtay

    Citation: BMC Clinical Pharmacology 2007 7:8

    Content type: Research article

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  37. A synergistic cytotoxic effect has been hypothesized for taxanes and capecitabine, a prodrug of 5-fluorouracil. Based on preclinical studies, this synergism has been attributed to an up-regulation of the enzym...

    Authors: Rupert Bartsch, Guenther G Steger, Birgit Forstner, Catharina Wenzel, Ursula Pluschnig, Blanka Rizovski, Gabriela Altorjai, Christoph C Zielinski and Robert M Mader

    Citation: BMC Clinical Pharmacology 2007 7:7

    Content type: Research article

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  38. Omeprazole is metabolized by the hepatic cytochrome P450 (CYP) 2C19 enzyme to 5-hydroxyomeprazole. CYP2C19 exhibits genetic polymorphisms responsible for the presence of poor metabolizers (PMs), intermediate m...

    Authors: Carlos Isaza, Julieta Henao, José H Isaza Martínez, Juan C Sepúlveda Arias and Leonardo Beltrán

    Citation: BMC Clinical Pharmacology 2007 7:6

    Content type: Research article

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  39. Both methadone- and buprenorphine-treated opioid-dependent patients frequently show cognitive deficits in attention, working memory, and verbal memory. However, no study has compared these patient groups with ...

    Authors: Pekka Rapeli, Carola Fabritius, Hannu Alho, Mikko Salaspuro, Kristian Wahlbeck and Hely Kalska

    Citation: BMC Clinical Pharmacology 2007 7:5

    Content type: Research article

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  40. A recent meta-analysis of drug effects in patients with hypertension claims that all β-adrenergic blockers are equally effective but less so than other antihypertensive drugs. Published comparisons of the β-ad...

    Authors: Ivar Aursnes, Jan-Bjørn Osnes, Ingunn Fride Tvete, Jørund Gåsemyr and Bent Natvig

    Citation: BMC Clinical Pharmacology 2007 7:4

    Content type: Correspondence

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  41. The purpose of this study was investigate the dose proportionality of a novel, once-daily, controlled-release formulation of hydromorphone that utilizes the OROS® Push-Pull™ osmotic pump technology.

    Authors: Gayatri Sathyan, Emily Xu, John Thipphawong and Suneel K Gupta

    Citation: BMC Clinical Pharmacology 2007 7:3

    Content type: Research article

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  42. The objective of this study was to compare the pharmacokinetic profile of a novel, once-daily, controlled-release formulation of hydromorphone (OROS® hydromorphone) under fasting conditions with that immediately ...

    Authors: Gayatri Sathyan, Emily Xu, John Thipphawong and Suneel K Gupta

    Citation: BMC Clinical Pharmacology 2007 7:2

    Content type: Research article

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  43. The long time pharmacokinetics of highly lipid soluble compounds is dominated by blood-adipose tissue exchange and depends on the magnitude and heterogeneity of adipose blood flow. Because the adipose tissue i...

    Authors: David G Levitt

    Citation: BMC Clinical Pharmacology 2007 7:1

    Content type: Research article

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  44. Inherited differences in the metabolism and disposition of drugs, and genetic polymorphisms in the targets of drug therapy (e.g., receptors), can greatly influence efficacy and toxicity of medications. Marked ...

    Authors: Tanmay S Panchabhai, Shaun F Noronha, Sanish Davis, Vishal M Shinde, Nilima A Kshirsagar and Nithya J Gogtay

    Citation: BMC Clinical Pharmacology 2006 6:8

    Content type: Research article

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  45. Finasteride is a competitive inhibitor of 5 alpha-reductase enzyme, and is used for treatment of benign prostatic hyperplasia and androgenetic alopecia. Animal studies have shown that finasteride might induce ...

    Authors: Babak Rahimi-Ardabili, Ramin Pourandarjani, Peiman Habibollahi and Amir Mualeki

    Citation: BMC Clinical Pharmacology 2006 6:7

    Content type: Research article

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