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Table 3 Pharmacokinetic geometric mean ratios of AVI-014/filgrastim at 4 μg/kg

From: A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study

PK parameter

Dose mcg/kg

Geo Mean AVI-014 (n = 16)

Geo Mean Filgrastin (n = 8)

P value

Geo Mean Ratio (90% CI)

AUC(0–72)

4

169.545

170,259

0.9766

1.00 (0.76, 1.31)

Cmax

4

18,830

21,855

0.2952

0.86 (0.66, 1.13)

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BMC Clinical Pharmacology

ISSN: 1472-6904