Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A - Medical results

Table 7 Comparison of average urine excretion of essential and other minerals compared to baseline.

	Baseline	st dev	Change after 1^stdose	Change after 9^thdose	RDA for 4-8 yr (mg)	% of RDA lost #
Cu	0.022	0.008	74%***	129%***	0.44	3%
K	2187	1491	110%***	48%**	1500	57%
Fe	0.016	0.055	93%+	64%	10	0.1%
Mn	0.0023	0.0016	77%***	37%*	1.5	<0.1%
Zi	0.00034	0.00069	90%	13%	n/a
Li	0.10	0.10	51%	50%	n/a
V	0.025	0.013	49%***	10%
Cr	0.091	0.044	47%***	11%	0.015	88%
Zn	0.81	0.49	8%	30%***	5	2%
Na	3901	2018	35%***	3%	n/a
B	2.5	2.0	25%*	11%	n/a
Ba	0.0050	0.0052	12%	22%	n/a
S	1140	694	3%	9%	n/a
Mg	168	64	-5%	17%*	130	4%
Se	0.20	0.16	3%	0%	30	6%
Co	0.0014	0.0013	-4%	4%	n/a
Ca	137	115	-6%	3%	800	no extra loss
St	0.25	0.15	-5%	0%	n/a
P	1160	627	-5%	-4%	500	No extraloss
Mo	0.13	0.13	-5%	-33%*	0.022	No extra loss

+ P < 0.1
*P < 0.05
** P < 0.01
*** P < 0.001
# Averaged over 3 days, assuming production of creatinine is 500 mcg/day, which is typical for a 60-pound child
N = 63. Units are mg/g-creatinine (note difference from table 2 and 3, which are mcg/g-creatinine). Arranged in approximate order of increase in urinary excretion. The extra loss of minerals due to increased urinary excretion is also listed in terms of the RDA. Results for potassium (K) and chromium (Cr) are highlighted due to the large % of RDA.