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Table 4 Total Amount of PEA and MHPG (mg) Excreted in the 24 Hour Urine Collection Prior to and After Application of the Selegiline Patch

From: A Phase 1 Trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion

Measure

Day 3–4

After Cocaine Preselegiline

Day 4–5

0–24 hr Postselegiline

Day 11–12

Selegiline Phase

1st Day After Cocaineâ–²

Day 12–13

Selegiline Phase

2nd Day After Cocaine†

DAY 13–14

Selegiline Phase

3rd Day After Cocaine‡

PEA

0.003 ± 0.004

0.132 ± 0.095*

0.260 ± 0.171****

0.229 ± 0.145****

0.159 ± 0.104**

MHPG-S

1.44 ± 0.43

1.43 ± 0.40

1.09 ± 0.23**

1.07 ± 0.40**

1.01 ± 0.33**

  1. Infusion started on Day 11 at 11 AM, on day 11, 2 hours after 9 AM patch application.
  2. â–² Selegiline patch applied @ 9 AM Day 12;
  3. † Selegiline patch applied @ 9 AM Day 13;
  4. ‡ No selegiline patch was applied at 9 AM on Day 14.
  5. * Changed from Day 3–4, p < 0.05
  6. ** Greater than Day 3–4, p < 0.01
  7. *** Greater than Day 3–4, p < 0.001
  8. **** Greater than Day 3–4, p < 0.0001
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BMC Clinical Pharmacology

ISSN: 1472-6904