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Table 4 Total Amount of PEA and MHPG (mg) Excreted in the 24 Hour Urine Collection Prior to and After Application of the Selegiline Patch

From: A Phase 1 Trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion

Measure Day 3–4
After Cocaine Preselegiline
Day 4–5
0–24 hr Postselegiline
Day 11–12
Selegiline Phase
1st Day After Cocaine
Day 12–13
Selegiline Phase
2nd Day After Cocaine
DAY 13–14
Selegiline Phase
3rd Day After Cocaine
PEA 0.003 ± 0.004 0.132 ± 0.095* 0.260 ± 0.171**** 0.229 ± 0.145**** 0.159 ± 0.104**
MHPG-S 1.44 ± 0.43 1.43 ± 0.40 1.09 ± 0.23** 1.07 ± 0.40** 1.01 ± 0.33**
  1. Infusion started on Day 11 at 11 AM, on day 11, 2 hours after 9 AM patch application.
  2. Selegiline patch applied @ 9 AM Day 12;
  3. † Selegiline patch applied @ 9 AM Day 13;
  4. ‡ No selegiline patch was applied at 9 AM on Day 14.
  5. * Changed from Day 3–4, p < 0.05
  6. ** Greater than Day 3–4, p < 0.01
  7. *** Greater than Day 3–4, p < 0.001
  8. **** Greater than Day 3–4, p < 0.0001