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Table 2 Selegiline and Metabolites Excreted in the 24 Hour Urines from 0–24, 24–48, and 48–72 hours After Cocaine (Mean ± SD, N = 12)

From: A Phase 1 Trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion

Drug Assayed 0–24 hours
(day 11)
24–48 hours
(day 12)
Statistical p Value
0–24 vs. 24–48 hours
48–72 hours
(day 13)
Selegiline 0.109 ± 0.073 0.145 ± 0.138 0.34 0.063 ± 0.097
Desmethylselegiline 0.184 ± 0.128 0.188 ± 0.162 0.75 0.082 ± 0.086
l-Methamphetamine 6.26 ± 2.28 8.51 ± 5.69 0.20 4.83 ± 1.55
l-Amphetamine 2.34 ± 0.85 3.30 ± 2.34 0.18 2.15 ± 0.94
  1. Infusion started on Day 11 at 11 AM, 2 hr after the 9 AM daily patch application.
  2. No selegiline daily patch was applied at 9 AM on day 14.