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Table 1 Plasma Pharmacokinetic Parameters for Cocaine and Benzoylecgonine

From: A Phase 1 Trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion

Substance

(mean ± SD)

Cmax

(ng/ml)

Tmax

(hr)

AUC

(0-t)

(ng*h/ml)

λz

(1/hr)

(t1/2)z

(hr)

AUC

(0-∞)

(ng*h/ml)

AUCext

(%)

CL

(ml/min/kg)

Vz

(l/kg)

Cocaine

Pre Selegiline

(session 1)

721 ± 773

2.66 ± 1.74

2640 ± 55.6

0.453 ± 27.9

1.71 ± 0.81

2680 ± 1470

1.40 ± 1.03

18.3 ± 6.17

2.49 ± 0.88

Cocaine

With Selegiline

(session 2)

640 ± 332

2.27 ± 2.04

2360 ± 499

0.456 ± 0.09

1.57 ± 0.30

2400 ± 487

1.78 ± 1.87

18.0 ± 3.34

2.44 ± 0.64

Benzoyl-ecgonine

Pre Selegiline

(session 1)

1045 ± 180

4.79 ± 0.50

13000 ± 3030

0.0928 ± 0.023

8.63 ± 5.36

13600 ± 3820

3.45 ± 6.45

  

Benzoyl-ecgonine

With Selegiline

(session 2)

957 ± 184

5.04 ± 0.65

12900 ± 3760

0.0971 ± 0.024

7.52 ± 1.82

13200 ± 4180

2.21 ± 2.24

  
  1. * Cmax = maximum plasma concentration; Tmax = time of Cmax; AUC(0-t) = area under the plasma concentration-time curve from 0 time to the time of the last measurable plasma concentration; AUC(0-∞) = area under the plasma concentration-time curve from 0 to infinity; AUCext (%) = percent of AUC(0-∞) determined by extrapolation; λz = "terminal" exponential rate constant; (t1/2)z = "terminal" exponential half-life; CL = clearance; Vz = "terminal" exponential volume of distribution; SD = standard deviation and %CV = percent coefficient of variation.