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Table 1 Plasma Pharmacokinetic Parameters for Cocaine and Benzoylecgonine

From: A Phase 1 Trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion

Substance
(mean ± SD)
Cmax
(ng/ml)
Tmax
(hr)
AUC
(0-t)
(ng*h/ml)
λz
(1/hr)
(t1/2)z
(hr)
AUC
(0-∞)
(ng*h/ml)
AUCext
(%)
CL
(ml/min/kg)
Vz
(l/kg)
Cocaine
Pre Selegiline
(session 1)
721 ± 773 2.66 ± 1.74 2640 ± 55.6 0.453 ± 27.9 1.71 ± 0.81 2680 ± 1470 1.40 ± 1.03 18.3 ± 6.17 2.49 ± 0.88
Cocaine
With Selegiline
(session 2)
640 ± 332 2.27 ± 2.04 2360 ± 499 0.456 ± 0.09 1.57 ± 0.30 2400 ± 487 1.78 ± 1.87 18.0 ± 3.34 2.44 ± 0.64
Benzoyl-ecgonine
Pre Selegiline
(session 1)
1045 ± 180 4.79 ± 0.50 13000 ± 3030 0.0928 ± 0.023 8.63 ± 5.36 13600 ± 3820 3.45 ± 6.45   
Benzoyl-ecgonine
With Selegiline
(session 2)
957 ± 184 5.04 ± 0.65 12900 ± 3760 0.0971 ± 0.024 7.52 ± 1.82 13200 ± 4180 2.21 ± 2.24   
  1. * Cmax = maximum plasma concentration; Tmax = time of Cmax; AUC(0-t) = area under the plasma concentration-time curve from 0 time to the time of the last measurable plasma concentration; AUC(0-∞) = area under the plasma concentration-time curve from 0 to infinity; AUCext (%) = percent of AUC(0-∞) determined by extrapolation; λz = "terminal" exponential rate constant; (t1/2)z = "terminal" exponential half-life; CL = clearance; Vz = "terminal" exponential volume of distribution; SD = standard deviation and %CV = percent coefficient of variation.