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Table 3 Pharmacokinetic profile

From: Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: The effect of water and timing of meal intake on oral delivery of Salmon Calcitonin

Study medication

Water Volume

Dose pre-meal

AUC0–4 pg/ml × hrs

Cmax pg/ml

Tmax minutes

SMC021

50 ml

10 min

52.2 (46.0–59.4)

103 (89–118)

15 (10–23)

SMC021

50 ml

30 min

68.9 (60.2–78.9)

125 (110–144)

15 (15–30)

SMC021

50 ml

60 min

74.4 (64.0–86.5)

145 (125–168)

15 (15–30)

SMC021

200 ml

10 min

27.4 (25.2–29.7)

52 (45–59)

15 (10–15)

SMC021

200 ml

30 min

32.9 (29.1–37.3)

56 (48–67)

15 (15–30)

SMC021

200 ml

60 min

33.6 (29.5–38.1)

49 (42–58)

15 (12.5–30)

Miacalcic

N/A

60 min

16.4 (13.8–19.4)

11.4 (8.3–15.5)

15 (10–15)

  1. AUC0–4 and Cmax is given as geometric mean (mean ± 1 sem), and Tmax as median (25–75 percentile)