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Table 3 Pharmacokinetic profile

From: Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: The effect of water and timing of meal intake on oral delivery of Salmon Calcitonin

Study medication Water Volume Dose pre-meal AUC0–4 pg/ml × hrs Cmax pg/ml Tmax minutes
SMC021 50 ml 10 min 52.2 (46.0–59.4) 103 (89–118) 15 (10–23)
SMC021 50 ml 30 min 68.9 (60.2–78.9) 125 (110–144) 15 (15–30)
SMC021 50 ml 60 min 74.4 (64.0–86.5) 145 (125–168) 15 (15–30)
SMC021 200 ml 10 min 27.4 (25.2–29.7) 52 (45–59) 15 (10–15)
SMC021 200 ml 30 min 32.9 (29.1–37.3) 56 (48–67) 15 (15–30)
SMC021 200 ml 60 min 33.6 (29.5–38.1) 49 (42–58) 15 (12.5–30)
Miacalcic N/A 60 min 16.4 (13.8–19.4) 11.4 (8.3–15.5) 15 (10–15)
  1. AUC0–4 and Cmax is given as geometric mean (mean ± 1 sem), and Tmax as median (25–75 percentile)