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Table 1 Treatments and Dosing Regimens

From: Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: The effect of water and timing of meal intake on oral delivery of Salmon Calcitonin

Treatment Number Study medication Water volume Dosing time pre-meal
1 n = 40 SMC021 0.8 mg 50 ml 10 min
2 n = 40 SMC021 0.8 mg 50 ml 30 min
3 n = 40 SMC021 0.8 mg 50 ml 60 min
4 n = 40 SMC021 0.8 mg 200 ml 10 min
5 n = 40 SMC021 0.8 mg 200 ml 30 min
6 n = 40 SMC021 0.8 mg 200 ml 60 min
7 n = 10 Placebo 200 ml 10 min
8 n = 10 Placebo 200 ml 30 min
9 n = 10 Placebo 200 ml 60 min
10 n = 10 Miacalcic®200 IU NS N/A 60 min