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Table 1 Treatments and Dosing Regimens

From: Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: The effect of water and timing of meal intake on oral delivery of Salmon Calcitonin

Treatment

Number

Study medication

Water volume

Dosing time pre-meal

1

n = 40

SMC021 0.8 mg

50 ml

10 min

2

n = 40

SMC021 0.8 mg

50 ml

30 min

3

n = 40

SMC021 0.8 mg

50 ml

60 min

4

n = 40

SMC021 0.8 mg

200 ml

10 min

5

n = 40

SMC021 0.8 mg

200 ml

30 min

6

n = 40

SMC021 0.8 mg

200 ml

60 min

7

n = 10

Placebo

200 ml

10 min

8

n = 10

Placebo

200 ml

30 min

9

n = 10

Placebo

200 ml

60 min

10

n = 10

Miacalcic®200 IU NS

N/A

60 min