Table 4 Peak Changes in VAS Subjective Variables in Response to Inhaled l-Methamphetamine, IV phenylephrine and IV l-methamphetamine.
From: The Clinical Pharmacology of Intranasal l-Methamphetamine
Measure | 16 Inhalations | 32 Inhalations | 64 Inhalations | PE1 | PE2 | IV l-Meth | Overall P-Value |
|---|---|---|---|---|---|---|---|
Any Drug Effect | 9.0 (13.9)§||** | 7.3 (10.5)§||** | 9.8 (7.9)§||¶** | 1.5 (2.1) | 1.7 (2.4) | 4.5 (8.6) | 0.001 |
Bad Drug Effect | 6.8 (13.7) | 2.8 (4.6) | 4.9 (5.0) | 0.33 (0.9) | 1.1 (0.79) | 5.3 (10.7) | 0.07 |
Dizziness | 9.3 (14.0)§||¶** | 6.5 (6.4)¶** | 9.0 (13.5)§||¶** | 1.5 (2.9) | 0.92 (2.2) | -0.67 (5.7) | 0.004 |
Good Drug Effect | 5.8 (13.0)||** | 5.7 (10.5)** | 9.7 (13.0)§||¶** | 0.42 (2.9) | 0.25 (1.5) | 2.7 (4.7) | 0.005 |
Headache | 5.1 (18.1) | 4.8 (5.1)|| | 12.7 (17.0)§||¶** | -0.08 (1.7) | 1.8 (3.3) | -3.8 (13.4) | 0.02 |
Nasal Dryness | 5.2 (16.2) | 3.3 (9.6) | 4.1 (9.9) | -0.75 (2.1) | -0.50 (1.7) | -0.42 (2.7) | 0.20 |
Nasal Stuffiness | 1.1 (16.9) | 2.8 (4.8) | 1.4 (6.7) | 0.50 (4.4) | -1.6 (3.6) | 0.42 (1.2) | 0.88 |