Table 3 Change in Cardiovascular Variables in Response to Inhaler Condition and IV l-Methamphetamine as Measured by Impedance Cardiography.
From: The Clinical Pharmacology of Intranasal l-Methamphetamine
Measure | 16 Inhalations | 32 Inhalations | 64 Inhalations | IV l-Meth | Overall P-Value (time) | Overall P-Value (dose) |
|---|---|---|---|---|---|---|
Cardiac Output (l/min) | ||||||
15 minutes | -0.53 (0.66) | -0.46 (1.3) | -0.56 (0.52) | -0.01 (0.54) | 0.02 | 0.67 |
2 Hours | 0.0 (0.67) | 0.05 (1.6) | 0.31 (0.77) | 0.28 (1.0) | 0.32 | |
Heart Rate (beats/min) | ||||||
15 Minutes | -2.6 (4.9) | -2.1 (5.8) | -1.7 (5.9) | 1.0 (5.8) | 0.38 | 0.60 |
2 Hours | 4.3 (6.0) | 5.4 (11.3) | 4.3 (7.7) | 6.1 (9.5) | 0.003 | |
Systolic Blood Pressure (mmHg) | ||||||
15 Minutes | 1.0 (12.5) | -1.2 (6.6) | -3.0 (6.4) | 4.8 (9.0) | 0.76 | 0.09 |
2 Hours | 1.8 (7.9) | -0.17 (7.0) | 3.1 (6.9) | 5.9 (6.9) | 0.06 | |
Diastolic Blood Pressure (mmHg) | ||||||
15 Minutes | 0.50 (7.5) | 1.4 (6.7) | 1.2 (6.4) | 4.3 (8.8) | 0.09 | 0.23 |
2 Hours | 2.2 (4.2) | 2.6 (6.5) | 1.2 (4.9) | 6.5 (8.1) | 0.007 | |
Stroke Volume | ||||||
15 Minutes | -3.9 (7.3) | -4.9 (16.0) | -6.0 (6.4) | -1.0 (5.4) | 0.008 | 0.66 |
2 Hours | -5.4 (6.6) | -6.2 (17.5) | -1.6 (7.8) | -0.67 (6.4) | 0.02 | |
Systemic Vascular Resistance (dynes*sec*cm5) | ||||||
15 Minutes | 106.0 (168.9) | 137.1 (388.5) | 129.1 (169.5) | 48.8 (112.7) | 0.004 | 0.89 |
2 Hours | 47.2 (140.2) | 72.0 (441.7) | -10.2 (204.0) | 12.3 (127.2) | 0.36 | |
Left CardiacWork | ||||||
15 Minutes | -0.51 (1.0) | -0.48 (1.6) | -0.59 (0.64) | 0.44 (0.93) | 0.21 | 0.12 |
2 Hours | 0.22 (0.91) | 0.23 (2.1) | 0.53 (0.78) | 1.1 (1.5) | 0.03 | |
LV Ejection Time | ||||||
15 Minutes | -0.75 (12.4) | -4.8 (16.4) | -12.4 (19.1) | -0.25 (10.4) | 0.19 | 0.54 |
2 Hours | -11.8 (16.4) | -12.1 (26.8) | -11.8 (19.9) | -6.4 (26.5) | 0.005 |