Table 2 Change in Cardiovascular Variables in Response to Exercise After Vicks Inhalation and IV l-Methamphetamine As Measured by Stress Echocardiography. Data presented as mean (SD).
From: The Clinical Pharmacology of Intranasal l-Methamphetamine
Measure | 16 Inhalations | 32 Inhalations | 64 Inhalations | IV l-Meth | Overall P-Value (time) | Overall P-Value (dose) |
|---|---|---|---|---|---|---|
Cardiac Output (l/min) | 3.1 (2.0) | 2.4 (2.2) | 2.5 (2.5) | 3.8 (2.3) | < 0.001 | 0.10 |
Heart Rate (beats/min) | 73.5 (26.7 | 66.3 (21.5) | 64.5 (22.9) | 76.9 (16.8) | < 0.001 | 0.17 |
Systolic Blood Pressure (mmHg) | 41.3 (18.7) | 41.6 (42.6) | 52.0 (13.9) | 57.6 (11.6) | < 0.001 | 0.35 |
Stroke Volume (ml) | 3.3 (13.2) | 2.5 (13.4) | 2.1 (13.9) | -0.02 (7.3) | 0.41 | 0.90 |
LV Internal Diameter (cm) | -2.6 (2.9) | -2.1 (3.5) | -1.8 (4.1) | -2.0 (4.6) | 0.01 | 0.96 |
Ejection Fraction (%) | 8.9 (5.8) | 7.8 (7.6) | 6.3 (6.4) | 9.9 (6.5) | < 0.001 | 0.62 |
Systolic Wall Stress(kdynes/cm2) | 64.5 (62.8) | 51.7 (61.6) | 41.7 (79.3) | 81.7 (90.6) | 0.002 | 0.42 |
Posterior Wall Thickness (cm) | - 0.58 (1.4) | 0.67 (1.3) | 0.25 (0.97) | 0.08 (1.5) | 0.49 | 0.20 |
Septal Wall Thickness (mm) | 0.08 (0.79) | 0.08 (1.5) | 2.0 (3.1) | 0.25 (0.97) | 0.05 | 0.04 |