Table 1 Table depicting drugs and nature of adverse events seen during the study

Anti tubercular agents (AKT)

52

HRZ (35), AKT (7), Rifampin (4), Ethambutol (2), Pyrazinamide (2) Streptomycin (1), Isoniazid(1),

Thrombocytopenia, Hepatitis, Hepatic encephalopathy, Retro bulbar neuritis, Cholestatic jaundice, Erythema multiforme, Vestibular toxicity, Gastritis, Abdominal/Respiratory/Flu like syndrome, Hypersensitivity reaction, Psychosis, Peripheral neuropathy, dysglycemia

Antiepileptics

36

Phenytoin(24), Valproate (5), Phenobarbiturate(4) carbamazepine (3)

Erythema multiforme, Symptomatic toxic carbamazepine/phenytoin/valproate levels with cerebellar signs

Antimalarials

30

Chloroquine (29), Sulfadoxine-pyrimethamine (1)

Gastritis, Giddiness, Erthyema multiforme, Psychosis, Hypersensitivity reactions, Hypotension

Anticoagulants

25

Warfarin (24), Heparin (1)

GI bleeding, haematuria, high INR, Intracranial bleed

Oral hypoglycemic agents (OHA)

16

Glibenclamide (10), Glyburide (6)

Hypoglycemia, seizures,

NSAIDS

14

Paracetamol (6), Aspirin (3), Ibuprofen (1), Etoricoxib (1), Nimesulide (2), Diclofenac (1)

Hypersensitivity reaction, Gastritis, mucosal damage, Hematuria, (Etoricoxib) potentiates OHA induced Hypoglycemia, ARF on CRF, Thrombocytopenia

Antihypertensives

10

Atenolol (4), ACE inhibitors (2), Losartan (2), Clonidine (1), Isosorbide dinitrate (1)

Hypotension, Hypersensitivity reaction, AV block, Bradycardia, Hyperkalemia, Missed dose of clonidine leading to rebound hypertension, dry mouth

Cytotoxic drugs

9

Methotrexate (3), 5-Fluorouracil (2), Cisplatin (1), Etoposide (1), Paclitaxel (1), Chemo (1)

Bone marrow suppression (with opportunistic infection), Nephrotoxicity, Liver damage, GI mucositis, Anorexia, Myelodysplastic syndrome, Alopecia, Hyperuricemia, Abdominal pain, Neutropenia

Steroids

9

Prednisolone (7), Betamethasone (2)

Gastritis, Hypertension, Hyperglycemia, Mania, Fragile skin, Facial puffiness, Osteoporosis, Opportunistic infections

Insulin

8

Humulin70/30 (8)

Hypoglycemia, Erythema/swelling/stinging at injection site

Digoxin

8

--

Symptomatic toxic digoxin levels

Fluoroquinolones

8

Ciprofloxacin(4), Ofloxacin (2) Gatifloxacin (2)

Complex partial seizures, Peripheral neuropathy, Dystonia, Hypersensitivity reaction, tendinitis, dysguesia

B lactam antibiotics

8

Amoxicillin(3), Ampicillin(2), Cefadroxil (1), Ceftriaxone (1), Ceftazidime (1)

Hypersensitivity reaction, Fixed drug eruptions, Diarrhea, muscle spasm, Generalized tonic-clonic seizure

Antiretrovirals

4

Efavirenz (2), Stavudine (1), Zidovudine (1)

Metabolic acidosis, Drowsiness, hypokalemia, Peripheral neuropathy

Benzodiazepines

4

Chlordiazepoxide (2), Diazepam (2)

Increased appetite and weight gain, Drowsiness, Ataxia, Amnesia, Vertigo

Bronchodilators

4

Salbutamol (3), Theophylline (1)

Tremors

Haematinics

3

Ferrous fumarate(2) Ferrous sulfate (1)

Epigastric pain, Heart burn, Vomiting, Metallic taste in mouth

Fibrinolytics

2

Urokinase (2)

Hypotension, AV block

Miscellaneous

15

Metronidazole (1) Nicotinic acid (1) Fluconazole (1) Ethamsylate (1) Amitriptyline (1) Cotrimoxazole (1) Oxybutinin HCl (1) Dextropropoxy- phene (1) Urograffin (1) Amikacin (1) Benzthiazide (1) Amiodarone (1) Levodopa (1) Alendronate (1) Clozapine (1)

Gastritis Facial flush, Hypersensitivity reaction (4) Thrombocytopenia, dry mouth Perioral tingling numbness, Carpopedal spasm, Cochlear toxicity Muscle Cramps, Paresthesias raised liver functions Peak dose dyskinesias Esophagitis, constipation, seizure