Drug Class/Drug | NO. (%) OF ADRS | Individual drugs | Adverse Event |
---|---|---|---|
Anti tubercular agents (AKT) | 52 | HRZ (35), AKT (7), Rifampin (4), Ethambutol (2), Pyrazinamide (2) Streptomycin (1), Isoniazid(1), | Thrombocytopenia, Hepatitis, Hepatic encephalopathy, Retro bulbar neuritis, Cholestatic jaundice, Erythema multiforme, Vestibular toxicity, Gastritis, Abdominal/Respiratory/Flu like syndrome, Hypersensitivity reaction, Psychosis, Peripheral neuropathy, dysglycemia |
Antiepileptics | 36 | Phenytoin(24), Valproate (5), Phenobarbiturate(4) carbamazepine (3) | Erythema multiforme, Symptomatic toxic carbamazepine/phenytoin/valproate levels with cerebellar signs |
Antimalarials | 30 | Chloroquine (29), Sulfadoxine-pyrimethamine (1) | Gastritis, Giddiness, Erthyema multiforme, Psychosis, Hypersensitivity reactions, Hypotension |
Anticoagulants | 25 | Warfarin (24), Heparin (1) | GI bleeding, haematuria, high INR, Intracranial bleed |
Oral hypoglycemic agents (OHA) | 16 | Glibenclamide (10), Glyburide (6) | Hypoglycemia, seizures, |
NSAIDS | 14 | Paracetamol (6), Aspirin (3), Ibuprofen (1), Etoricoxib (1), Nimesulide (2), Diclofenac (1) | Hypersensitivity reaction, Gastritis, mucosal damage, Hematuria, (Etoricoxib) potentiates OHA induced Hypoglycemia, ARF on CRF, Thrombocytopenia |
Antihypertensives | 10 | Atenolol (4), ACE inhibitors (2), Losartan (2), Clonidine (1), Isosorbide dinitrate (1) | Hypotension, Hypersensitivity reaction, AV block, Bradycardia, Hyperkalemia, Missed dose of clonidine leading to rebound hypertension, dry mouth |
Cytotoxic drugs | 9 | Methotrexate (3), 5-Fluorouracil (2), Cisplatin (1), Etoposide (1), Paclitaxel (1), Chemo (1) | Bone marrow suppression (with opportunistic infection), Nephrotoxicity, Liver damage, GI mucositis, Anorexia, Myelodysplastic syndrome, Alopecia, Hyperuricemia, Abdominal pain, Neutropenia |
Steroids | 9 | Prednisolone (7), Betamethasone (2) | Gastritis, Hypertension, Hyperglycemia, Mania, Fragile skin, Facial puffiness, Osteoporosis, Opportunistic infections |
Insulin | 8 | Humulin70/30 (8) | Hypoglycemia, Erythema/swelling/stinging at injection site |
Digoxin | 8 | -- | Symptomatic toxic digoxin levels |
Fluoroquinolones | 8 | Ciprofloxacin(4), Ofloxacin (2) Gatifloxacin (2) | Complex partial seizures, Peripheral neuropathy, Dystonia, Hypersensitivity reaction, tendinitis, dysguesia |
B lactam antibiotics | 8 | Amoxicillin(3), Ampicillin(2), Cefadroxil (1), Ceftriaxone (1), Ceftazidime (1) | Hypersensitivity reaction, Fixed drug eruptions, Diarrhea, muscle spasm, Generalized tonic-clonic seizure |
Antiretrovirals | 4 | Efavirenz (2), Stavudine (1), Zidovudine (1) | Metabolic acidosis, Drowsiness, hypokalemia, Peripheral neuropathy |
Benzodiazepines | 4 | Chlordiazepoxide (2), Diazepam (2) | Increased appetite and weight gain, Drowsiness, Ataxia, Amnesia, Vertigo |
Bronchodilators | 4 | Salbutamol (3), Theophylline (1) | Tremors |
Haematinics | 3 | Ferrous fumarate(2) Ferrous sulfate (1) | Epigastric pain, Heart burn, Vomiting, Metallic taste in mouth |
Fibrinolytics | 2 | Urokinase (2) | Hypotension, AV block |
Miscellaneous | 15 | Metronidazole (1) Nicotinic acid (1) Fluconazole (1) Ethamsylate (1) Amitriptyline (1) Cotrimoxazole (1) Oxybutinin HCl (1) Dextropropoxy- phene (1) Urograffin (1) Amikacin (1) Benzthiazide (1) Amiodarone (1) Levodopa (1) Alendronate (1) Clozapine (1) | Gastritis Facial flush, Hypersensitivity reaction (4) Thrombocytopenia, dry mouth Perioral tingling numbness, Carpopedal spasm, Cochlear toxicity Muscle Cramps, Paresthesias raised liver functions Peak dose dyskinesias Esophagitis, constipation, seizure |