|
Solute
|
Ref
|
Ave F l/kg/min
|
F1 l/kg/min
|
V1 fract
|
F2 l/kg/min
|
V2 fract
|
F3 l/kg/min
|
V2 fract
|
Time
|
Method
|
|---|
|
Volatile Anesthetics
|
This ms.
|
0.044
|
0.0739
|
0.5
|
0.0141
|
0.5
| | |
6 days
|
PBPK N = 2
|
| | |
0.044
|
0.095
|
0.33
|
0.031
|
0.33
|
0.0059
|
0.33
|
6 days
|
PBPK N = 3
|
| |
[38]
|
0.071
|
0.213
|
.26
|
0.022
|
0.74
| | |
5 days
|
PBPK N = 2
|
| | |
0.05
|
0.097
|
.41
|
0.019
|
0.59
| | | | |
| |
[4, 5]
|
0.06–0.071
|
.11–.15
|
≈ 0.5
|
0.021–0.024
|
≈ 0.5
| | |
6 days
|
Compartmental
|
|
Propofol
|
[14]
|
0.042
|
0.042
|
1.0
| | | | |
600 min
|
PBPK N = 1
|
|
Toluene
|
[55]
|
0.032
|
0.032
|
1.0
| | | | |
4 days
|
PBPK N = 1
|
|
Toluene
|
[53]
|
0.024
|
0.042
|
0.4
|
0.013
|
0.5
|
0.0
|
0.1
|
20 hr
|
PBPK N = 2
|
|
Styrene
|
[54]
|
0.028
|
0.052
|
0.4
|
0.014
|
0.5
|
0.0
|
0.1
|
20 hr
|
PBPK N = 2
|
- (Vi = fraction of total adipose volume in compartment i; Fi = perfusion rate in compartment i). (Note: in toluene [53] and styrene [54] PBPK model it is assumed that 10% of the adipose tissue has zero blood flow).
