Heterogeneity of human adipose blood flow

Table 1 Model human adipose blood flow heterogeneity.

Solute	Ref	Ave F l/kg/min	F₁ l/kg/min	V₁ fract	F₂ l/kg/min	V₂ fract	F₃ l/kg/min	V₂ fract	Time	Method
Volatile Anesthetics	This ms.	0.044	0.0739	0.5	0.0141	0.5			6 days	PBPK N = 2
		0.044	0.095	0.33	0.031	0.33	0.0059	0.33	6 days	PBPK N = 3
	[38]	0.071	0.213	.26	0.022	0.74			5 days	PBPK N = 2
		0.05	0.097	.41	0.019	0.59
	[4, 5]	0.06–0.071	.11–.15	≈ 0.5	0.021–0.024	≈ 0.5			6 days	Compartmental
Propofol	[14]	0.042	0.042	1.0					600 min	PBPK N = 1
Toluene	[55]	0.032	0.032	1.0					4 days	PBPK N = 1
Toluene	[53]	0.024	0.042	0.4	0.013	0.5	0.0	0.1	20 hr	PBPK N = 2
Styrene	[54]	0.028	0.052	0.4	0.014	0.5	0.0	0.1	20 hr	PBPK N = 2

(V_i = fraction of total adipose volume in compartment i; F_i = perfusion rate in compartment i). (Note: in toluene [53] and styrene [54] PBPK model it is assumed that 10% of the adipose tissue has zero blood flow).