Table 1 Voriconazole (VOR) and sulphobutylether beta cyclodextrin sodium (SBECD) plasma levels in patients with intravenous voriconazole therapy and renal failure

1

2

2 × 400 mg

2 × 6400 mg

before dialysis

0.9

98.3

1

2

2 × 200 mg

2 × 3200 mg

after dialysis

1.1

145

1

3

2 × 200 mg

2 × 3200 mg

before dialysis

0.2

93.3

1

4

2 × 200 mg

2 × 3200 mg

after dialysis

< 0.2

121

1

7

2 × 200 mg

2 × 3200 mg

after dialysis

0.4

78.9

1

8

2 × 200 mg

2 × 3200 mg

before dialysis

0.5

86.4

1

9

2 × 200 mg

2 × 3200 mg

before dialysis

0.4

59.6

1

9

2 × 200 mg

2 × 3200 mg

after dialysis

< 0.2

31.4

1

10

2 × 200 mg

2 × 3200 mg

before dialysis

0.3

71.6

1

12

2 × 200 mg

2 × 3200 mg

no dialysis

< 0.2

15.6

1

13

2 × 200 mg

2 × 3200 mg

no dialysis

< 0.2

16.4

1

16

2 × 200 mg

2 × 3200 mg

no dialysis

< 0.2

18.4

2

10

2 × 200 mg

2 × 3200 mg

before dialysis

0.4

523

2

11

2 × 200 mg

2 × 3200 mg

after dialysis

0.3

400

2

12

2 × 200 mg

2 × 3200 mg

no dialysis

0.3

348

2

13

2 × 200 mg

2 × 3200 mg

no dialysis

0.7

508

3

4

2 × 400 mg

2 × 6400 mg

no dialysis

3.8

110

3

8

2 × 400 mg

2 × 6400 mg

before dialysis

5.1

314

3

10

2 × 400 mg

2 × 6400 mg

after dialysis

3.2

409

3

11

2 × 400 mg

2 × 6400 mg

after dialysis

2.6

200

4

1

2 × 400 mg

2 × 6400 mg

before dialysis

1.4

344

4

5

2 × 200 mg

2 × 3200 mg

before dialysis

0.3

271

4

7

2 × 200 mg

2 × 3200 mg

before dialysis

0.3

451

4

8

2 × 200 mg

2 × 3200 mg

after dialysis

0.3

483

4

9

2 × 200 mg

2 × 3200 mg

no dialysis

0.9

456

4

12

2 × 200 mg

2 × 3200 mg

after dialysis

1.1

505

4

13

2 × 200 mg

2 × 3200 mg

before dialysis

1.3

581

4

13

2 × 200 mg

2 × 3200 mg

after dialysis

0.9

563