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Table 1 Voriconazole (VOR) and sulphobutylether beta cyclodextrin sodium (SBECD) plasma levels in patients with intravenous voriconazole therapy and renal failure

From: Accumulation of the solvent vehicle sulphobutylether beta cyclodextrin sodium in critically ill patients treated with intravenous voriconazole under renal replacement therapy

patient no. day of VOR therapy dose of intravenous VOR dose of SBECD dialysis information VOR (μg/ml) SBECD (μg/ml)
1 2 2 × 400 mg 2 × 6400 mg before dialysis 0.9 98.3
1 2 2 × 200 mg 2 × 3200 mg after dialysis 1.1 145
1 3 2 × 200 mg 2 × 3200 mg before dialysis 0.2 93.3
1 4 2 × 200 mg 2 × 3200 mg after dialysis < 0.2 121
1 7 2 × 200 mg 2 × 3200 mg after dialysis 0.4 78.9
1 8 2 × 200 mg 2 × 3200 mg before dialysis 0.5 86.4
1 9 2 × 200 mg 2 × 3200 mg before dialysis 0.4 59.6
1 9 2 × 200 mg 2 × 3200 mg after dialysis < 0.2 31.4
1 10 2 × 200 mg 2 × 3200 mg before dialysis 0.3 71.6
1 12 2 × 200 mg 2 × 3200 mg no dialysis < 0.2 15.6
1 13 2 × 200 mg 2 × 3200 mg no dialysis < 0.2 16.4
1 16 2 × 200 mg 2 × 3200 mg no dialysis < 0.2 18.4
2 10 2 × 200 mg 2 × 3200 mg before dialysis 0.4 523
2 11 2 × 200 mg 2 × 3200 mg after dialysis 0.3 400
2 12 2 × 200 mg 2 × 3200 mg no dialysis 0.3 348
2 13 2 × 200 mg 2 × 3200 mg no dialysis 0.7 508
3 4 2 × 400 mg 2 × 6400 mg no dialysis 3.8 110
3 8 2 × 400 mg 2 × 6400 mg before dialysis 5.1 314
3 10 2 × 400 mg 2 × 6400 mg after dialysis 3.2 409
3 11 2 × 400 mg 2 × 6400 mg after dialysis 2.6 200
4 1 2 × 400 mg 2 × 6400 mg before dialysis 1.4 344
4 5 2 × 200 mg 2 × 3200 mg before dialysis 0.3 271
4 7 2 × 200 mg 2 × 3200 mg before dialysis 0.3 451
4 8 2 × 200 mg 2 × 3200 mg after dialysis 0.3 483
4 9 2 × 200 mg 2 × 3200 mg no dialysis 0.9 456
4 12 2 × 200 mg 2 × 3200 mg after dialysis 1.1 505
4 13 2 × 200 mg 2 × 3200 mg before dialysis 1.3 581
4 13 2 × 200 mg 2 × 3200 mg after dialysis 0.9 563