Time course of total (free and conjugated) plasma concentrations of M1, U5 and U6. These compounds had a tmaxaround ten hours. Symbols represent time course of mean and standard deviation of concentrations after a single dose of 300 mg Pycnogenol. The column represents mean and standard deviation of M1 concentrations after repeated doses of 200 mg Pycnogenol daily after five days. Steady state concentrations of U5 and U6 were detectable in one, respectively two volunteers and are not shown in this diagram.