Figure 3From: Single and multiple dose pharmacokinetics of maritime pine bark extract (Pycnogenol) after oral administration to healthy volunteersTime course of total (free and conjugated) plasma concentrations of taxifolin, U8 and U9. These compounds had a tmax between five and ten hours. Symbols represent time course of mean and standard deviation of concentrations after a single dose of 300 mg Pycnogenol. No steady state concentrations after repeated doses of 200 mg Pycnogenol daily were detectable after five days.Back to article page