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Table 3 Serum concentrations for morphine and metabolites for the oral route The morphine doses (mg/24 h) vary because of variable doses of rescue morphine. A total of 23 trial periods in 19 patients were studied. All data are given as median and range.

From: Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study

  Day 1 Day 2 Day 3 Day 4
Morphine dose (mg/24 h) 90 (20–1460) 80 (20 – 1700) 95 (30 – 1520) 90 (20 – 1580)
Serum morphine (nmol/l) 255 (46–2520) 59 (17–1437) 94 (12–1429) 77 (9–2296)
Serum M6G (nmol/l) 1156 (149–7874) 568 (66–7874) 516 (66–9678) 620 (80–8026)
Serum M3G (nmol/l) 6341 (1734–31997) 3696 (404–36887) 3226 (595–41452) 3778 (526–43043)