Table 3 Serum concentrations for morphine and metabolites for the oral route The morphine doses (mg/24 h) vary because of variable doses of rescue morphine. A total of 23 trial periods in 19 patients were studied. All data are given as median and range.
Day 1 | Day 2 | Day 3 | Day 4 | |
|---|---|---|---|---|
Morphine dose (mg/24 h) | 90 (20–1460) | 80 (20 – 1700) | 95 (30 – 1520) | 90 (20 – 1580) |
Serum morphine (nmol/l) | 255 (46–2520) | 59 (17–1437) | 94 (12–1429) | 77 (9–2296) |
Serum M6G (nmol/l) | 1156 (149–7874) | 568 (66–7874) | 516 (66–9678) | 620 (80–8026) |
Serum M3G (nmol/l) | 6341 (1734–31997) | 3696 (404–36887) | 3226 (595–41452) | 3778 (526–43043) |