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Table 1 Percentage unbound (free) drug concentrations of naproxen, warfarin, and digitoxin in various albumin solutions

From: Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro

 

Naproxen 0.1 mmol/L

Warfarin 0.05 mmol/L

Digitoxin 0.02 mmol/L

Human serum

0.07 (0.02)%

0.7 (0.2)%

4.9 (0.2)%

Sigma albumin

0.04 (0.01)%

1.1 (0.2)%

5.1 (0.4)%

Baxter/Immuno

2.77 (0.09)%*

4.1 (0.2)%*

11.1 (0.3)%*

Pharmacia & Upjohn

3.15 (0.17)%*

5.2 (0.5)%*

11.5 (0.4)%*

Octapharma

2.61 (0.10)%*

4.8 (0.3)%*

10.0 (0.4)%*

  1. Percent free drug concentrations of naproxen, warfarin, and digitoxin calculated from the results obtained by ultrafiltration of the albumin solutions and human serum. The solutions were diluted to the final albumin concentration of 0.615 mmol/L. Values are means (SDs) of five separate experiments. * p < 0.05 compared with Sigma albumin and human serum.
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BMC Clinical Pharmacology

ISSN: 1472-6904